Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF [PDF]
, 2002 Injury to peripheral nerves results in the infiltration of immune cells, which remove axonal- and myelin-derived material. Schwann cells could play a key role in this process by regulating macrophage infiltration.
Jessen, KR +3 more
core +2 more sources
BMC Chemistry, 2023 As an essential marker of cancer treatment, PARP-1 inhibitors could effectively kill tumor cells through a mechanism known as synthetic lethality and are used to treat a variety of cancers.
Ling Yu +6 more
doaj +1 more source
Astrocyte Pannexin 1 Suppresses LPS-Induced Inflammatory Responses to Protect Neuronal SH-SY5Y Cells
Frontiers in Cellular Neuroscience, 2021 Reactive astrogliosis is a key hallmark of inflammatory responses in the pathogenesis of brain injury, including Parkinson’s disease (PD), but its role and regulatory mechanisms are not fully understood.
Zhuo-Min Ling +8 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2023 Background: Intervertebral disc degeneration (IDD) is the leading cause of lower back pain, and an overall understanding of the molecular mechanisms related to IDD is still lacking. The purpose of this study was to explore gene signatures and immune cell
Tao Tang +17 more
doaj +1 more source
Long-term functional recovery after facial nerve transection and repair in the rat [PDF]
, 2015 BACKGROUND: The rodent model is commonly used to study facial nerve injury. Because of the exceptional regenerative capacity of the rodent facial nerve, it is essential to consider the timing when studying facial nerve regeneration and functional ...
Banks, Caroline A +5 more
core +2 more sources
Differential Gene Expression in Primary Cultured Sensory and Motor Nerve Fibroblasts
Frontiers in Neuroscience, 2019 Fibroblasts (Fbs) effectively promote Schwann cells (SCs) migration, proliferation, and neurite regeneration. Whether Fbs express different motor and sensory phenotypes that regulate the cell behavior and peripheral nerve function has not been elucidated.
Qianru He +6 more
doaj +1 more source
Schwann cells and mesenchymal stem cells in laminin- or fibronectin-aligned matrices and regeneration across a critical size defect of 15 mm in the rat sciatic nerve [PDF]
, 2018 OBJECTIVE Artificial nerve guides are being developed to substitute for autograft repair after peripheral nerve injuries. However, the use of conduits is limited by the length of the gap that needs to be bridged, with the success of regeneration highly ...
Gonzalez-Perez, F +5 more
core +1 more source
Neuron-autonomous transcriptome changes upon ischemia/reperfusion injury
Scientific Reports, 2017 Ischemic stroke and the following reperfusion, an acute therapeutic intervention, can cause irreversible brain damages. However, the underlying pathological mechanisms are still under investigation.
Jinlong Shi +7 more
doaj +1 more source
Brachial plexus injury mimicking a spinal-cord injury. [PDF]
, 2010 Objective High-energy impact to the head, neck, and shoulder can result in cervical spine as well as brachial plexus injuries. Because cervical spine injuries are more common, this tends to be the initial focus for management.
Aversano, Michael +5 more
core +1 more source
BMC Neurology, 2022 Background Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation to modulate cortical activity for improving motor function.
Pei-Ling Wong +4 more
doaj +1 more source