Results 21 to 30 of about 157,358 (309)

Aligned Polyhydroxyalkanoate Blend Electrospun Fibers as Intraluminal Guidance Scaffolds for Peripheral Nerve Repair [PDF]

, 2023
The use of nerve guidance conduits (NGCs) to treat peripheral nerve injuries is a favorable approach to the current “gold standard” of autografting. However, as simple hollow tubes, they lack specific topographical and mechanical guidance cues present in
Claeyssens, F., Gregory, D., Nigmatullin, R., Roy, Ipsita, Lukasiewicz, Barbara B., Taylor, C., Behbehani, Mehri, Glen, Adam, Basnett, Pooja, Haycock, John W.   +9 more
core   +1 more source

Differential Gene Expression in Primary Cultured Sensory and Motor Nerve Fibroblasts

Frontiers in Neuroscience, 2019
Fibroblasts (Fbs) effectively promote Schwann cells (SCs) migration, proliferation, and neurite regeneration. Whether Fbs express different motor and sensory phenotypes that regulate the cell behavior and peripheral nerve function has not been elucidated.
Qianru He, Mi Shen, Fang Tong, Meng Cong, Shibo Zhang, Yanpei Gong, Fei Ding   +6 more
doaj   +1 more source

Discovery of novel 2,3,4,5-tetrahydrospiro[benzo[c]azepine-1,1’-cyclohexan]-5-ol derivatives as PARP-1 inhibitors

BMC Chemistry, 2023
As an essential marker of cancer treatment, PARP-1 inhibitors could effectively kill tumor cells through a mechanism known as synthetic lethality and are used to treat a variety of cancers.
Ling Yu, Jian-hui Li, Ju Zhu, You-de Wang, Zhi-wei Yan, Li-ying Zhang, Shuai Li   +6 more
doaj   +1 more source

Advanced Nanoparticle-Engineered Platforms for Peripheral Nerve Repair: Multimodal Therapeutic Strategies and Clinical Translation. [PDF]

Int J Nanomedicine
Shaoyan Shi,1 Xingxing Yu,2 Xuehai Ou,1 Changming Zheng,1 Fei Xie,1 Yansheng Huang3 1Department of Hand Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, 710000, People’s Republic of China; 2Department of Laboratory Medicine, Xi’ an ...
Shi S, Yu X, Ou X, Zheng C, Xie F, Huang Y.   +5 more
europepmc   +2 more sources

Facial Nerve Repair following Acute Nerve Injury

, 2022
Background  Acute facial nerve iatrogenic or traumatic injury warrants rapid management with the goal of reestablishing nerve continuity within 72 hours.
Yanko, Ravit, Daniel J. Kedar, Ravit Yanko, Zaretski, Arik, Arad, Ehud, Arik Zaretski, Dan M. Fliss, Eyal Gur, Fliss, Ehud, Ehud Fliss, Ehud Arad, Gur, Eyal, Tulchinsky, Roei, Roei Tulchinsky, Fliss, Dan M., Kedar, Daniel J.   +15 more
core   +1 more source

Neuron-autonomous transcriptome changes upon ischemia/reperfusion injury

Scientific Reports, 2017
Ischemic stroke and the following reperfusion, an acute therapeutic intervention, can cause irreversible brain damages. However, the underlying pathological mechanisms are still under investigation.
Jinlong Shi, Xia Chen, Haiying Li, Youjia Wu, Shouyan Wang, Wei Shi, Jian Chen, Yaohui Ni   +7 more
doaj   +1 more source

Biodegradable materials for bone defect repair

Military Medical Research, 2020
Compared with non-degradable materials, biodegradable biomaterials play an increasingly important role in the repairing of severe bone defects, and have attracted extensive attention from researchers.
Shuai Wei, Jian-Xiong Ma, Lai Xu, Xiao-Song Gu, Xin-Long Ma   +4 more
doaj   +1 more source

Comparing different montages of transcranial direct current stimulation on dual-task walking and cortical activity in chronic stroke: double-blinded randomized controlled trial

BMC Neurology, 2022
Background Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation to modulate cortical activity for improving motor function.
Pei-Ling Wong, Yea-Ru Yang, Shun-Chang Tang, Shih-Fong Huang, Ray-Yau Wang   +4 more
doaj   +1 more source

Developmental Temporal Patterns and Molecular Network Features in the Transcriptome of Rat Spinal Cord

Engineering, 2021
The molecular network features of spinal cord development that are integral to tissue engineering remain poorly understood in placental mammals, especially in terms of their relationships with vital biological processes such as regeneration.
Jian Yang, Lili Zhao, Sheng Yi, Fei Ding, Yumin Yang, Yan Liu, Yongjun Wang, Mei Liu, Chengbin Xue, Lian Xu, Leilei Gong, Xinghui Wang, Yu Zhang, Bin Yu, Guo-li Ming, Xiaosong Gu   +15 more
doaj   +1 more source

Identification of hub genes related to the innate immune response activated during spinal cord injury

FEBS Open Bio, 2022
Spinal cord injury (SCI) often leads to sensory and motor dysfunction. Two major factors that hinder spinal cord repair are local inflammation and glial scar formation after SCI, and thus appropriate immunotherapy may alleviate damage.
Jianfeng Li, Xizhe Liu, Huachuan Wu, Peng Guo, Baoliang Li, Jianmin Wang, Wei Tian, Dafu Chen, Manman Gao, Zhiyu Zhou, Shaoyu Liu   +10 more
doaj   +1 more source