Results 21 to 30 of about 1,041,327 (245)

Differential Gene Expression in Primary Cultured Sensory and Motor Nerve Fibroblasts

Frontiers in Neuroscience, 2019
Fibroblasts (Fbs) effectively promote Schwann cells (SCs) migration, proliferation, and neurite regeneration. Whether Fbs express different motor and sensory phenotypes that regulate the cell behavior and peripheral nerve function has not been elucidated.
Qianru He, Mi Shen, Fang Tong, Meng Cong, Shibo Zhang, Yanpei Gong, Fei Ding   +6 more
doaj   +1 more source

Discovery of novel 2,3,4,5-tetrahydrospiro[benzo[c]azepine-1,1’-cyclohexan]-5-ol derivatives as PARP-1 inhibitors

BMC Chemistry, 2023
As an essential marker of cancer treatment, PARP-1 inhibitors could effectively kill tumor cells through a mechanism known as synthetic lethality and are used to treat a variety of cancers.
Ling Yu, Jian-hui Li, Ju Zhu, You-de Wang, Zhi-wei Yan, Li-ying Zhang, Shuai Li   +6 more
doaj   +1 more source

Olfactory Ensheathing Cells for Spinal Cord Injury: The Cellular Superpowers for Nerve Repair

, 2022
Neurotrauma injuries are notoriously difficult to deal with both clinically as well as experimentally, as the cellular and molecular events ensuing after injury complicate the neuroinflammatory processes.
Francesca Oieni, James St John, Oieni, Francesca, Reshamwala, Ronak, St John, James, Ronak Reshamwala   +5 more
core   +1 more source

Comparing different montages of transcranial direct current stimulation on dual-task walking and cortical activity in chronic stroke: double-blinded randomized controlled trial

BMC Neurology, 2022
Background Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation to modulate cortical activity for improving motor function.
Pei-Ling Wong, Yea-Ru Yang, Shun-Chang Tang, Shih-Fong Huang, Ray-Yau Wang   +4 more
doaj   +1 more source

Developmental Temporal Patterns and Molecular Network Features in the Transcriptome of Rat Spinal Cord

Engineering, 2021
The molecular network features of spinal cord development that are integral to tissue engineering remain poorly understood in placental mammals, especially in terms of their relationships with vital biological processes such as regeneration.
Jian Yang, Lili Zhao, Sheng Yi, Fei Ding, Yumin Yang, Yan Liu, Yongjun Wang, Mei Liu, Chengbin Xue, Lian Xu, Leilei Gong, Xinghui Wang, Yu Zhang, Bin Yu, Guo-li Ming, Xiaosong Gu   +15 more
doaj   +1 more source

Amyotrophic Lateral Sclerosis: Molecular Mechanisms, Biomarkers, and Therapeutic Strategies

Antioxidants, 2021
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with the progressive loss of motor neurons, leading to a fatal paralysis. According to whether there is a family history of ALS, ALS can be roughly divided into two types: familial and ...
Xiaoming Yang, Yanan Ji, Wei Wang, Lilei Zhang, Zehao Chen, Miaomei Yu, Yuntian Shen, Fei Ding, Xiaosong Gu, Hualin Sun   +9 more
doaj   +1 more source

Skeletal Muscle Atrophy Was Alleviated by Salidroside Through Suppressing Oxidative Stress and Inflammation During Denervation

Frontiers in Pharmacology, 2019
Skeletal muscle atrophy is a common and debilitating condition that lacks an effective therapy. Oxidative stress and inflammation are two main molecular mechanisms involved in muscle atrophy.
Ziwei Huang, Ziwei Huang, Qingqing Fang, Wenjing Ma, Qiuyu Zhang, Jiaying Qiu, Xiaosong Gu, Huilin Yang, Hualin Sun   +8 more
doaj   +1 more source

Biodegradable materials for bone defect repair

Military Medical Research, 2020
Compared with non-degradable materials, biodegradable biomaterials play an increasingly important role in the repairing of severe bone defects, and have attracted extensive attention from researchers.
Shuai Wei, Jian-Xiong Ma, Lai Xu, Xiao-Song Gu, Xin-Long Ma   +4 more
doaj   +1 more source

Identification of hub genes related to the innate immune response activated during spinal cord injury

FEBS Open Bio, 2022
Spinal cord injury (SCI) often leads to sensory and motor dysfunction. Two major factors that hinder spinal cord repair are local inflammation and glial scar formation after SCI, and thus appropriate immunotherapy may alleviate damage.
Jianfeng Li, Xizhe Liu, Huachuan Wu, Peng Guo, Baoliang Li, Jianmin Wang, Wei Tian, Dafu Chen, Manman Gao, Zhiyu Zhou, Shaoyu Liu   +10 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source