Results 1 to 10 of about 1,101,918 (298)

Differential Gene Expression in Primary Cultured Sensory and Motor Nerve Fibroblasts

Frontiers in Neuroscience, 2019
Fibroblasts (Fbs) effectively promote Schwann cells (SCs) migration, proliferation, and neurite regeneration. Whether Fbs express different motor and sensory phenotypes that regulate the cell behavior and peripheral nerve function has not been elucidated.
Qianru He, Mi Shen, Fang Tong, Meng Cong, Shibo Zhang, Yanpei Gong, Fei Ding   +6 more
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Developmental Temporal Patterns and Molecular Network Features in the Transcriptome of Rat Spinal Cord

Engineering, 2021
The molecular network features of spinal cord development that are integral to tissue engineering remain poorly understood in placental mammals, especially in terms of their relationships with vital biological processes such as regeneration.
Jian Yang, Lili Zhao, Sheng Yi, Fei Ding, Yumin Yang, Yan Liu, Yongjun Wang, Mei Liu, Chengbin Xue, Lian Xu, Leilei Gong, Xinghui Wang, Yu Zhang, Bin Yu, Guo-li Ming, Xiaosong Gu   +15 more
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Comparing different montages of transcranial direct current stimulation on dual-task walking and cortical activity in chronic stroke: double-blinded randomized controlled trial

BMC Neurology, 2022
Background Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation to modulate cortical activity for improving motor function.
Pei-Ling Wong, Yea-Ru Yang, Shun-Chang Tang, Shih-Fong Huang, Ray-Yau Wang   +4 more
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Amyotrophic Lateral Sclerosis: Molecular Mechanisms, Biomarkers, and Therapeutic Strategies

Antioxidants, 2021
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with the progressive loss of motor neurons, leading to a fatal paralysis. According to whether there is a family history of ALS, ALS can be roughly divided into two types: familial and ...
Xiaoming Yang, Yanan Ji, Wei Wang, Lilei Zhang, Zehao Chen, Miaomei Yu, Yuntian Shen, Fei Ding, Xiaosong Gu, Hualin Sun   +9 more
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Skeletal Muscle Atrophy Was Alleviated by Salidroside Through Suppressing Oxidative Stress and Inflammation During Denervation

Frontiers in Pharmacology, 2019
Skeletal muscle atrophy is a common and debilitating condition that lacks an effective therapy. Oxidative stress and inflammation are two main molecular mechanisms involved in muscle atrophy.
Ziwei Huang, Ziwei Huang, Qingqing Fang, Wenjing Ma, Qiuyu Zhang, Jiaying Qiu, Xiaosong Gu, Huilin Yang, Hualin Sun   +8 more
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Biodegradable materials for bone defect repair

Military Medical Research, 2020
Compared with non-degradable materials, biodegradable biomaterials play an increasingly important role in the repairing of severe bone defects, and have attracted extensive attention from researchers.
Shuai Wei, Jian-Xiong Ma, Lai Xu, Xiao-Song Gu, Xin-Long Ma   +4 more
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Identification of hub genes related to the innate immune response activated during spinal cord injury

FEBS Open Bio, 2022
Spinal cord injury (SCI) often leads to sensory and motor dysfunction. Two major factors that hinder spinal cord repair are local inflammation and glial scar formation after SCI, and thus appropriate immunotherapy may alleviate damage.
Jianfeng Li, Xizhe Liu, Huachuan Wu, Peng Guo, Baoliang Li, Jianmin Wang, Wei Tian, Dafu Chen, Manman Gao, Zhiyu Zhou, Shaoyu Liu   +10 more
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Intradiscal injection for the management of low back pain

JOR Spine, 2022
Low back pain (LBP) is a common clinical problem and a major cause of physical disability, imposing a prominent socioeconomic burden. Intervertebral disc degeneration (IDD) has been considered the main cause of LBP.
Fu Zhang, Songjuan Wang, Baoliang Li, Wei Tian, Zhiyu Zhou, Shaoyu Liu   +5 more
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The Schwann cell-specific G-protein Gαo (Gnao1) is a cell-intrinsic controller contributing to the regulation of myelination in peripheral nerve system

Acta Neuropathologica Communications
Myelin sheath abnormality is the cause of various neurodegenerative diseases (NDDs). G-proteins and their coupled receptors (GPCRs) play the important roles in myelination. Gnao1, encoding the major Gα protein (Gαo) in mammalian nerve system, is required
Jinghui Xu, Qianqian Peng, Jieyi Cai, Jianghong Shangguan, Wenfeng Su, Gang Chen, Hualin Sun, Changlai Zhu, Yun Gu   +8 more
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Spectrum and signals of medication-associated cognitive disorder: a comprehensive disproportionality analysis with cross-database validation

Frontiers in Pharmacology
ObjectiveThe clinical risk of cognitive disorders linked to various drugs is not well-defined. This study aimed to identify medications with notable signals for drug-related cognitive disorders and evaluate whether their US Food and Drug Administration ...
Hao Wen, Yajie Dong, Ruiting Wang
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