Results 61 to 70 of about 1,694,794 (371)

Salidroside Attenuates Denervation-Induced Skeletal Muscle Atrophy Through Negative Regulation of Pro-inflammatory Cytokine

Frontiers in Physiology, 2019
Skeletal muscle atrophy is associated with pro-inflammatory cytokines. Salidroside is a biologically active ingredient of Rhodiola rosea, which exhibits anti-inflammatory property.
Changyue Wu, Changyue Wu, Longhai Tang, Xuejun Ni, Tongtong Xu, Qingqing Fang, Lai Xu, Wenjing Ma, Xiaoming Yang, Hualin Sun   +9 more
doaj   +1 more source

Iron role paradox in nerve degeneration and regeneration [PDF]

Bolandghamat, S., & Behnam-Rassouli, M. (2024). Iron role paradox in nerve degeneration and regeneration. Physiological Reports, 12, e15908
Iron accumulates in the neural tissue during peripheral nerve degeneration. Some studies have already been suggested that iron facilitates Wallerian degeneration (WD) events such as Schwann cell de-differentiation. On the other hand, intracellular iron levels remain elevated during nerve regeneration and gradually decrease.
arxiv   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

A coordination model for ultra-large scale systems of systems [PDF]

EPTCS 133, 2013, pp. 84-98, 2013
The ultra large multi-agent systems are becoming increasingly popular due to quick decay of the individual production costs and the potential of speeding up the solving of complex problems. Examples include nano-robots, or systems of nano-satellites for dangerous meteorite detection, or cultures of stem cells for organ regeneration or nerve repair. The
arxiv   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Animal models used to study direct peripheral nerve repair: a systematic review

Neural Regeneration Research, 2019
Objective: Peripheral nerve repair is required after traumatic injury. This common condition represents a major public health problem worldwide. Recovery after nerve repair depends on several factors, including the severity of the injury, the nerve ...
F. Vela, G. Martínez-Chacón, A. Ballestín, J. L. Campos, F. Sánchez-Margallo, E. Abellán   +5 more
semanticscholar   +1 more source

The Schwann cell-specific G-protein Gαo (Gnao1) is a cell-intrinsic controller contributing to the regulation of myelination in peripheral nerve system

Acta Neuropathologica Communications
Myelin sheath abnormality is the cause of various neurodegenerative diseases (NDDs). G-proteins and their coupled receptors (GPCRs) play the important roles in myelination. Gnao1, encoding the major Gα protein (Gαo) in mammalian nerve system, is required
Jinghui Xu, Qianqian Peng, Jieyi Cai, Jianghong Shangguan, Wenfeng Su, Gang Chen, Hualin Sun, Changlai Zhu, Yun Gu   +8 more
doaj   +1 more source

Pathological Grade-Associated Transcriptome Profiling of lncRNAs and mRNAs in Gliomas

Frontiers in Oncology, 2020
The aim of the present study was to explore the expression profiles of lncRNAs and mRNAs in glioma patients and to elucidate any potential relationship between lncRNAs and mRNAs in glioma.
Junlong Sun, Junlong Sun, Junlong Sun, Rui Jiang, Rui Jiang, Mengruo Song, Mengruo Song, Junzhong Yao, Junzhong Yao, Shiqiang Hou, Yunhua Zhu, Yunhua Zhu, Xiang Ji, Xiang Ji, Hao Sheng, Zhongyu Tang, Zhongyu Tang, Qianqian Liu, Qianqian Liu, Zhongzheng Jia, Wei Shi, Wei Shi, Jinlong Shi, Jinlong Shi   +23 more
doaj   +1 more source

HDAC4 Knockdown Alleviates Denervation-Induced Muscle Atrophy by Inhibiting Myogenin-Dependent Atrogene Activation

Frontiers in Cellular Neuroscience, 2021
Denervation can activate the catabolic pathway in skeletal muscle and lead to progressive skeletal muscle atrophy. At present, there is no effective treatment for muscle atrophy. Histone deacetylase 4 (HDAC4) has recently been found to be closely related
Wenjing Ma, Yong Cai, Yuntian Shen, Xin Chen, Lilei Zhang, Yanan Ji, Zehao Chen, Jianwei Zhu, Xiaoming Yang, Hualin Sun   +9 more
doaj   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source