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Photofabricated Gelatin-Based Nerve Conduits: Nerve Tissue Regeneration Potentials

Cell Transplantation, 2004
There is a strong demand for development of nerve guide conduit with prompt nerve regeneration potential for injury-induced nerve defect. Prior to study on nerve tissue engineering using Schwann cells or nerve stem cells, the effectiveness of ...
Eduardo Gámez, Yoshinobu Goto, Kengo Nagata, Toru Iwaki, Tomio Sasaki, Takehisa Matsuda Ph.D.   +5 more
doaj   +3 more sources

Characterization of circular RNAs in dorsal root ganglia after central and peripheral axon injuries

Frontiers in Cellular Neuroscience, 2022
In central nervous system, axons fail to regenerate after injury while in peripheral nervous system, axons retain certain regenerative ability. Dorsal root ganglion (DRG) neuron has an ascending central axon branch and a descending peripheral axon branch
Hong-Jun Cao, Li Huang, Meng-Ru Zheng, Tao Zhang, Ling-Chi Xu   +4 more
doaj   +1 more source

The transcription factor Stat-1 is essential for Schwann cell differentiation, myelination and myelin sheath regeneration

Molecular Medicine, 2023
Background Myelin sheath is a crucial accessory to the functional nerve-fiber unit, its disruption or loss can lead to axonal degeneration and subsequent neurodegenerative diseases (NDs).
Jinghui Xu, Bin Zhang, Jieyi Cai, Qianqian Peng, Junxia Hu, Parizat Askar, Jianghong Shangguan, Wenfeng Su, Changlai Zhu, Hualin Sun, Songlin Zhou, Gang Chen, Xiaoming Yang, Yun Gu   +13 more
doaj   +1 more source

Progress in methods for evaluating Schwann cell myelination and axonal growth in peripheral nerve regeneration via scaffolds

Frontiers in Bioengineering and Biotechnology, 2023
Peripheral nerve injury (PNI) is a neurological disorder caused by trauma that is frequently induced by accidents, war, and surgical complications, which is of global significance.
Jue Ling, Chang He, Shuxuan Zhang, Yahong Zhao, Meifeng Zhu, Xiaoxuan Tang, Qiaoyuan Li, Liming Xu, Yumin Yang   +8 more
doaj   +1 more source

Amyotrophic Lateral Sclerosis: Molecular Mechanisms, Biomarkers, and Therapeutic Strategies

Antioxidants, 2021
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with the progressive loss of motor neurons, leading to a fatal paralysis. According to whether there is a family history of ALS, ALS can be roughly divided into two types: familial and ...
Xiaoming Yang, Yanan Ji, Wei Wang, Lilei Zhang, Zehao Chen, Miaomei Yu, Yuntian Shen, Fei Ding, Xiaosong Gu, Hualin Sun   +9 more
doaj   +1 more source

Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration

Nanotechnology Reviews, 2021
Successful repair of long-distance peripheral nerve injuries remains a challenge in the clinic. Rapid axon growth is a key to accelerate nerve regeneration.
Gu Xinyi, Chen Xiaoli, Tang Xiaoxuan, Zhou Zhihao, Huang Tingting, Yang Yumin, Ling Jue   +6 more
doaj   +1 more source

Light-Triggered Adhesive Silk-Based Film for Effective Photodynamic Antibacterial Therapy and Rapid Hemostasis

Frontiers in Bioengineering and Biotechnology, 2022
Successful control of massive hemorrhage in deep wounds with irregular shape and low elasticity still remains great challenges in the clinic. As the wound sites are usually at risk of bacterial infection, it is necessary to design an ideal hemostatic ...
Tingting Huang, Zhihao Zhou, Qiaoyuan Li, Xiaoxuan Tang, Xiaoxuan Tang, Xiaoli Chen, Yifan Ge, Jue Ling   +7 more
doaj   +1 more source

Inhibition of Schwann cell pannexin 1 attenuates neuropathic pain through the suppression of inflammatory responses

Journal of Neuroinflammation, 2022
Background Neuropathic pain is still a challenge for clinical treatment as a result of the comprehensive pathogenesis. Although emerging evidence demonstrates the pivotal role of glial cells in regulating neuropathic pain, the role of Schwann cells and ...
Qian Wang, Han-yang Li, Zhuo-min Ling, Gang Chen, Zhong-Ya Wei   +4 more
doaj   +1 more source

Regenerative Role of T Cells in Nerve Repair and Functional Recovery

Frontiers in Immunology, 2022
The immune system is essential in the process of nerve repair after injury. Successful modulation of the immune response is regarded as an effective approach to improving treatment outcomes.
Xiaoxuan Tang, Xiaoxuan Tang, Qiaoyuan Li, Tingting Huang, Han Zhang, Xiaoli Chen, Jue Ling, Yumin Yang   +7 more
doaj   +1 more source

SKP-SC-EVs Mitigate Denervated Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation and Improving Microcirculation

Antioxidants, 2021
Denervated muscle atrophy is a common clinical disease that has no effective treatments. Our previous studies have found that oxidative stress and inflammation play an important role in the process of denervated muscle atrophy.
Wei Wang, Dingding Shen, Lilei Zhang, Yanan Ji, Lai Xu, Zehao Chen, Yuntian Shen, Leilei Gong, Qi Zhang, Mi Shen, Xiaosong Gu, Hualin Sun   +11 more
doaj   +1 more source