Results 41 to 50 of about 869,390 (314)

Salidroside Attenuates Denervation-Induced Skeletal Muscle Atrophy Through Negative Regulation of Pro-inflammatory Cytokine

Frontiers in Physiology, 2019
Skeletal muscle atrophy is associated with pro-inflammatory cytokines. Salidroside is a biologically active ingredient of Rhodiola rosea, which exhibits anti-inflammatory property.
Changyue Wu, Changyue Wu, Longhai Tang, Xuejun Ni, Tongtong Xu, Qingqing Fang, Lai Xu, Wenjing Ma, Xiaoming Yang, Hualin Sun   +9 more
doaj   +1 more source

Transcriptome Analysis of Immune Receptor Activation and Energy Metabolism Reduction as the Underlying Mechanisms in Interleukin-6-Induced Skeletal Muscle Atrophy

Frontiers in Immunology, 2021
BackgroundInflammation may trigger skeletal muscle atrophy induced by cancer cachexia. As a pro-inflammatory factor, interleukin-6 may cause skeletal muscle atrophy, but the underlying molecular mechanisms have not been explored.MethodsIn this ...
Hualin Sun, Hualin Sun, Junjie Sun, Ming Li, Lei Qian, Lilei Zhang, Ziwei Huang, Ziwei Huang, Yuntian Shen, Betty Yuen-Kwan Law, Liang Liu, Xiaosong Gu   +11 more
doaj   +1 more source

Sympathetic nerve-derived ATP regulates renal medullary vasa recta diameter via pericyte cells: a role for regulating medullary blood flow? [PDF]

, 2013
Pericyte cells are now known to be a novel locus of blood flow control, being able to regulate capillary diameter via their unique morphology and expression of contractile proteins.
Crawford, C., Kelly, M. C., Kennedy-Lydon, T. M., Peppiatt-Wildman, Claire M., Wildman, Scott S.P.   +4 more
core   +2 more sources

Pathological Grade-Associated Transcriptome Profiling of lncRNAs and mRNAs in Gliomas

Frontiers in Oncology, 2020
The aim of the present study was to explore the expression profiles of lncRNAs and mRNAs in glioma patients and to elucidate any potential relationship between lncRNAs and mRNAs in glioma.
Junlong Sun, Junlong Sun, Junlong Sun, Rui Jiang, Rui Jiang, Mengruo Song, Mengruo Song, Junzhong Yao, Junzhong Yao, Shiqiang Hou, Yunhua Zhu, Yunhua Zhu, Xiang Ji, Xiang Ji, Hao Sheng, Zhongyu Tang, Zhongyu Tang, Qianqian Liu, Qianqian Liu, Zhongzheng Jia, Wei Shi, Wei Shi, Jinlong Shi, Jinlong Shi   +23 more
doaj   +1 more source

Adenosine monophosphate activated protein kinase contributes to skeletal muscle health through the control of mitochondrial function

Frontiers in Pharmacology, 2022
Skeletal muscle is one of the largest organs in the body and the largest protein repository. Mitochondria are the main energy-producing organelles in cells and play an important role in skeletal muscle health and function.
Yan Yan, Yan Yan, Ming Li, Jie Lin, Yanan Ji, Kexin Wang, Dajun Yan, Yuntian Shen, Wei Wang, Wei Wang, Zhongwei Huang, Haiyan Jiang, Hualin Sun, Lei Qi   +13 more
doaj   +1 more source

Photofabricated Gelatin-Based Nerve Conduits: Nerve Tissue Regeneration Potentials

Cell Transplantation, 2004
There is a strong demand for development of nerve guide conduit with prompt nerve regeneration potential for injury-induced nerve defect. Prior to study on nerve tissue engineering using Schwann cells or nerve stem cells, the effectiveness of photofabricated scaffolds based on photocurable gelatin was examined.
Eduardo Gámez, Yoshinobu Goto, Kengo Nagata, Toru Iwaki, Tomio Sasaki, Takehisa Matsuda Ph.D.   +5 more
openaire   +3 more sources

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

The Schwann cell-specific G-protein Gαo (Gnao1) is a cell-intrinsic controller contributing to the regulation of myelination in peripheral nerve system

Acta Neuropathologica Communications
Myelin sheath abnormality is the cause of various neurodegenerative diseases (NDDs). G-proteins and their coupled receptors (GPCRs) play the important roles in myelination. Gnao1, encoding the major Gα protein (Gαo) in mammalian nerve system, is required
Jinghui Xu, Qianqian Peng, Jieyi Cai, Jianghong Shangguan, Wenfeng Su, Gang Chen, Hualin Sun, Changlai Zhu, Yun Gu   +8 more
doaj   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Investigating the effect of photodynamic therapy on nerves using tissue engineered culture models [PDF]

, 2006
Introduction: Photodynamic therapy (PDT) shows potential as an effective treatment for prostate cancer. Clinical observations indicate that this approach causes fewer nerve damage related side-effects than conventional treatments.
Brown, R.A., Liniker, E, MacRobert, A.J., Phillips, J.B., Saffrey, M.J., Wright, K.E.   +5 more
core   +1 more source