Results 11 to 20 of about 871,938 (336)

Inhibition of Schwann cell pannexin 1 attenuates neuropathic pain through the suppression of inflammatory responses

Journal of Neuroinflammation, 2022
Background Neuropathic pain is still a challenge for clinical treatment as a result of the comprehensive pathogenesis. Although emerging evidence demonstrates the pivotal role of glial cells in regulating neuropathic pain, the role of Schwann cells and ...
Qian Wang, Han-yang Li, Zhuo-min Ling, Gang Chen, Zhong-Ya Wei   +4 more
doaj   +1 more source

Regenerative Role of T Cells in Nerve Repair and Functional Recovery

Frontiers in Immunology, 2022
The immune system is essential in the process of nerve repair after injury. Successful modulation of the immune response is regarded as an effective approach to improving treatment outcomes.
Xiaoxuan Tang, Xiaoxuan Tang, Qiaoyuan Li, Tingting Huang, Han Zhang, Xiaoli Chen, Jue Ling, Yumin Yang   +7 more
doaj   +1 more source

SKP-SC-EVs Mitigate Denervated Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation and Improving Microcirculation

Antioxidants, 2021
Denervated muscle atrophy is a common clinical disease that has no effective treatments. Our previous studies have found that oxidative stress and inflammation play an important role in the process of denervated muscle atrophy.
Wei Wang, Dingding Shen, Lilei Zhang, Yanan Ji, Lai Xu, Zehao Chen, Yuntian Shen, Leilei Gong, Qi Zhang, Mi Shen, Xiaosong Gu, Hualin Sun   +11 more
doaj   +1 more source

HDAC4 Knockdown Alleviates Denervation-Induced Muscle Atrophy by Inhibiting Myogenin-Dependent Atrogene Activation

Frontiers in Cellular Neuroscience, 2021
Denervation can activate the catabolic pathway in skeletal muscle and lead to progressive skeletal muscle atrophy. At present, there is no effective treatment for muscle atrophy. Histone deacetylase 4 (HDAC4) has recently been found to be closely related
Wenjing Ma, Yong Cai, Yuntian Shen, Xin Chen, Lilei Zhang, Yanan Ji, Zehao Chen, Jianwei Zhu, Xiaoming Yang, Hualin Sun   +9 more
doaj   +1 more source

The Effect of Schwann Cells/Schwann Cell-Like Cells on Cell Therapy for Peripheral Neuropathy

Frontiers in Cellular Neuroscience, 2022
Peripheral neuropathy is a common neurological issue that leads to sensory and motor disorders. Over time, the treatment for peripheral neuropathy has primarily focused on medications for specific symptoms and surgical techniques.
Qian Wang, Fang-Yu Chen, Zhuo-Min Ling, Wen-Feng Su, Ya-Yu Zhao, Gang Chen, Gang Chen, Gang Chen, Zhong-Ya Wei   +8 more
doaj   +1 more source

Isoquercitrin Delays Denervated Soleus Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation

Frontiers in Physiology, 2020
Although denervated muscle atrophy is common, the underlying molecular mechanism remains unelucidated. We have previously found that oxidative stress and inflammatory response may be early events that trigger denervated muscle atrophy. Isoquercitrin is a
Yuntian Shen, Qiuyu Zhang, Ziwei Huang, Jianwei Zhu, Jiayi Qiu, Wenjing Ma, Xiaoming Yang, Fei Ding, Hualin Sun   +8 more
doaj   +1 more source

The success of biomaterial-based tissue engineering strategies for peripheral nerve regeneration

Frontiers in Bioengineering and Biotechnology, 2022
Peripheral nerve injury is a clinically common injury that causes sensory dysfunction and locomotor system degeneration, which seriously affects the quality of the patients’ daily life.
Yuhui Jiang, Yuhui Jiang, Xiaoxuan Tang, Xiaoxuan Tang, Tao Li, Jue Ling, Yumin Yang, Yumin Yang   +7 more
doaj   +1 more source

Identification of Regulatory Factors and Prognostic Markers in Amyotrophic Lateral Sclerosis

Antioxidants, 2022
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive degeneration of motor neurons, leading to muscle atrophy, paralysis and even death.
Hualin Sun, Ming Li, Yanan Ji, Jianwei Zhu, Zehao Chen, Lilei Zhang, Chunyan Deng, Qiong Cheng, Wei Wang, Yuntian Shen, Dingding Shen   +10 more
doaj   +1 more source

Nerve cell differentiation in hydra requires two signals [PDF]

, 1986
Endogenous signals controlling nerve cell commitment in hydra were investigated using an assay for committed nerve precursors. Extracts of hydra tissue were prepared and tested for their ability to induce nerve cell commitment.
Berking, Berking, Bode, Bode, Bodenmüller, Campbell, David, David, David, David, David, Gierer, Grimmelikhuijzen, Holstein, Kemmner, MacWilliams, Schaller, Schaller, Schaller, Schaller, Schaller, Schaller, Schaller, Venugopal, Venugopal, Venugopal, Yaross, Yaross, Yaross   +28 more
core   +1 more source

Inflammation: Roles in Skeletal Muscle Atrophy

Antioxidants, 2022
Various diseases can cause skeletal muscle atrophy, usually accompanied by inflammation, mitochondrial dysfunction, apoptosis, decreased protein synthesis, and enhanced proteolysis.
Yanan Ji, Ming Li, Mengyuan Chang, Ruiqi Liu, Jiayi Qiu, Kexin Wang, Chunyan Deng, Yuntian Shen, Jianwei Zhu, Wei Wang, Lingchi Xu, Hualin Sun   +11 more
doaj   +1 more source