Results 251 to 260 of about 869,390 (314)

Diels‐Alder Click Chemistry as a Dynamic‐Covalent Crosslinking Method in Spheroid‐Encapsulating Hydrogels for Cartilage Engineering

open access: yesAdvanced Healthcare Materials, EarlyView.
This research shows the development of hydrogels with Diels‐Alder click chemistry for engineering cartilage‐like tissue. The hydrogels support cartilage spheroids which could be cultured for at least 28 days. Furthermore, the spheroids showed a tendency to fuse together into a more consistent construct, and produced important components needed for ...
Sanne M. van de Looij   +8 more
wiley   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

open access: yesAdvanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best   +5 more
wiley   +1 more source

Wound Geometry Determines Whether Aligned‐Fiber Scaffolds Accelerate or Impede Diabetic Wound Healing: A Biased Random Walk Analysis

open access: yesAdvanced Healthcare Materials, EarlyView.
Wound closure is governed by geometry‐orientation coupling: aligned fibers speed migration along their axis but hinder perpendicular advance. In vivo diabetic wound experiments with composition‐matched fibrin, combined with an anisotropic diffusion (biased random‐walk) model, quantify this trade‐off and generate a healing landscape.
Yin‐Yuan Huang   +13 more
wiley   +1 more source

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

open access: yesAdvanced Healthcare Materials, EarlyView.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan   +12 more
wiley   +1 more source

Soft Neural Interfaces for Circuit‐Level Analysis of Magnetogenetic Deep Brain Stimulation in Parkinson's Disease Models

open access: yesAdvanced Healthcare Materials, EarlyView.
ABSTRACT Magnetogenetic deep brain stimulation (MG‐DBS) represents a wireless neuromodulation that has demonstrated long‐lasting behavioral benefits in Parkinson's disease models. However, the circuit‐level mechanisms underlying these therapeutic effects have remained uncharacterized due to limitations of conventional neural interfaces.
Jakyoung Lee   +10 more
wiley   +1 more source
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Tissue Specificity in Nerve Regeneration

Scandinavian Journal of Plastic and Reconstructive Surgery, 1986
In 1944 Weiss & Taylor presented experimental evidence against "neurotropism" in nerve regeneration. We used a silicone Y-chamber system to repeat some of those experiments. The proximal stump of transected rat sciatic nerve was introduced into the proximal inlet of the Y. One of the distal outlets was left empty, plugged or occupied by a tendon graft,
G, Lundborg   +3 more
openaire   +2 more sources

Nerve as a Tissue

Neurology, 1967
Of the three stated goals of this symposium two have been amply realized. All those interested in basic research can become acquainted with the work of colleagues in other fields, and clinicians may gain a glimpse of what is new. But the book fails to attain the third goal, of providing information immediately pertinent to diagnosis and patient care ...
  +5 more sources

Nerve Tissue Engineering

2011
In this chapter, we aim at providing an up-to-date review on nerve tissue engineering, focusing on both the peripheral and the central nervous systems (PNS and CNS, respectively). After introducing the pathophysiology of nerves and the social impact of nerve injuries, we overview the therapeutic approaches oriented toward inducing nerve regeneration ...
SANNINO, Alessandro   +4 more
openaire   +2 more sources

Magnetic Stimulation of Nerve Tissue

Medical & Biological Engineering, 1973
A new principle for stimulating excitable tissue has been investigated in frog nerve-muscle preparations. The nerve was placed in, a high-frequency stationary magnetic field (1 kHz to 1 MHz) and the isometric contraction of the muscle was used as a measure of the stimulatory effect.
openaire   +2 more sources

Nerve as a Tissue

Science, 1965
Of the three stated goals of this symposium two have been amply realized. All those interested in basic research can become acquainted with the work of colleagues in other fields, and clinicians may gain a glimpse of what is new. But the book fails to attain the third goal, of providing information immediately pertinent to diagnosis and patient care ...
openaire   +2 more sources

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