Results 31 to 40 of about 537,672 (265)

Recent advances in NIR-II fluorescence based theranostic approaches for glioma

Frontiers in Chemistry, 2022
Gliomas are among the most common malignant tumors in the central nervous system and lead to poor life expectancy. However, the effective treatment of gliomas remains a considerable challenge.
Jiaying Li, Jiaying Li, Jue Ling, Chaoyi Yao   +3 more
doaj   +1 more source

Near-Infrared Spectral Similarity between Ex Vivo Porcine and In Vivo Human Tissue

Life, 2023
Background: In vivo diffuse reflectance spectroscopy provides additional contrast in discriminating nerves embedded in adipose tissue during surgery. However, large datasets are required to achieve clinically acceptable classification levels.
Eva de Vries, Lejla Alic, Rutger M. Schols, Kaj S. Emanuel, Fokko P. Wieringa, Nicole D. Bouvy, Gabriëlle J. M. Tuijthof   +6 more
doaj   +1 more source

Salidroside Attenuates Denervation-Induced Skeletal Muscle Atrophy Through Negative Regulation of Pro-inflammatory Cytokine

Frontiers in Physiology, 2019
Skeletal muscle atrophy is associated with pro-inflammatory cytokines. Salidroside is a biologically active ingredient of Rhodiola rosea, which exhibits anti-inflammatory property.
Changyue Wu, Changyue Wu, Longhai Tang, Xuejun Ni, Tongtong Xu, Qingqing Fang, Lai Xu, Wenjing Ma, Xiaoming Yang, Hualin Sun   +9 more
doaj   +1 more source

Pathological Grade-Associated Transcriptome Profiling of lncRNAs and mRNAs in Gliomas

Frontiers in Oncology, 2020
The aim of the present study was to explore the expression profiles of lncRNAs and mRNAs in glioma patients and to elucidate any potential relationship between lncRNAs and mRNAs in glioma.
Junlong Sun, Junlong Sun, Junlong Sun, Rui Jiang, Rui Jiang, Mengruo Song, Mengruo Song, Junzhong Yao, Junzhong Yao, Shiqiang Hou, Yunhua Zhu, Yunhua Zhu, Xiang Ji, Xiang Ji, Hao Sheng, Zhongyu Tang, Zhongyu Tang, Qianqian Liu, Qianqian Liu, Zhongzheng Jia, Wei Shi, Wei Shi, Jinlong Shi, Jinlong Shi   +23 more
doaj   +1 more source

Transcriptome Analysis of Immune Receptor Activation and Energy Metabolism Reduction as the Underlying Mechanisms in Interleukin-6-Induced Skeletal Muscle Atrophy

Frontiers in Immunology, 2021
BackgroundInflammation may trigger skeletal muscle atrophy induced by cancer cachexia. As a pro-inflammatory factor, interleukin-6 may cause skeletal muscle atrophy, but the underlying molecular mechanisms have not been explored.MethodsIn this ...
Hualin Sun, Hualin Sun, Junjie Sun, Ming Li, Lei Qian, Lilei Zhang, Ziwei Huang, Ziwei Huang, Yuntian Shen, Betty Yuen-Kwan Law, Liang Liu, Xiaosong Gu   +11 more
doaj   +1 more source

Adenosine monophosphate activated protein kinase contributes to skeletal muscle health through the control of mitochondrial function

Frontiers in Pharmacology, 2022
Skeletal muscle is one of the largest organs in the body and the largest protein repository. Mitochondria are the main energy-producing organelles in cells and play an important role in skeletal muscle health and function.
Yan Yan, Yan Yan, Ming Li, Jie Lin, Yanan Ji, Kexin Wang, Dajun Yan, Yuntian Shen, Wei Wang, Wei Wang, Zhongwei Huang, Haiyan Jiang, Hualin Sun, Lei Qi   +13 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The Schwann cell-specific G-protein Gαo (Gnao1) is a cell-intrinsic controller contributing to the regulation of myelination in peripheral nerve system

Acta Neuropathologica Communications
Myelin sheath abnormality is the cause of various neurodegenerative diseases (NDDs). G-proteins and their coupled receptors (GPCRs) play the important roles in myelination. Gnao1, encoding the major Gα protein (Gαo) in mammalian nerve system, is required
Jinghui Xu, Qianqian Peng, Jieyi Cai, Jianghong Shangguan, Wenfeng Su, Gang Chen, Hualin Sun, Changlai Zhu, Yun Gu   +8 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source