Results 51 to 60 of about 1,193,059 (373)

New insights into the interplay between autophagy and oxidative and endoplasmic reticulum stress in neuronal cell death and survival

Frontiers in Cell and Developmental Biology, 2022
Autophagy is a dynamic process that maintains the normal homeostasis of cells by digesting and degrading aging proteins and damaged organelles. The effect of autophagy on neural tissue is still a matter of debate.
Yahao Gao, Changshui Wang, Di Jiang, Gang An, Feng Jin, Junchen Zhang, Guangkui Han, Changmeng Cui, Pei Jiang   +8 more
doaj   +1 more source

Proteomic profiling of neuromas reveals alterations in protein composition and local protein synthesis in hyper-excitable nerves

Molecular Pain, 2008
Neuropathic pain may arise following peripheral nerve injury though the molecular mechanisms associated with this are unclear. We used proteomic profiling to examine changes in protein expression associated with the formation of hyper-excitable neuromas ...
Timms John F, Cramer Rainer, Okuse Kenji, Roza Carolina, Cendan Cruz-Miguel, Huang Hong-Lei, Wood John N   +6 more
doaj   +1 more source

Time course analysis of sensory axon regeneration in vivo by directly tracing regenerating axons

Neural Regeneration Research, 2020
Most current studies quantify axon regeneration by immunostaining regeneration-associated proteins, representing indirect measurement of axon lengths from both sensory neurons in the dorsal root ganglia and motor neurons in the spinal cord.
Yan Gao, Yi-Wen Hu, Run-Shan Duan, Shu-Guang Yang, Feng-Quan Zhou, Rui-Ying Wang   +5 more
doaj   +1 more source

Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior [PDF]

, 2006
The S100 family protein p11 (S100A10, annexin 2 light chain) is involved in the trafficking of the voltage-gated sodium channel Na(V)1.8, TWIK-related acid-sensitive K+ channel (TASK-1), the ligand-gated ion channels acid-sensing ion channel 1a (ASIC1a ...
Baker, MD, Dickenson, AH, Foulkes, T, Gerke, V, Lane, T, Matthews, EA, Nassar, MA, Okuse, K, Wood, JN   +8 more
core   +1 more source

Differential gene and protein expression between rat tibial nerve and common peroneal nerve during Wallerian degeneration

Neural Regeneration Research, 2019
Wallerian degeneration and nerve regeneration after injury are complex processes involving many genes, proteins and cytokines. After different peripheral nerve injuries the regeneration rate can differ.
Yao-Fa Lin, Zheng Xie, Jun Zhou, Gang Yin, Hao-Dong Lin   +4 more
doaj   +1 more source

Sub-Chronic Neuropathological and Biochemical Changes in Mouse Visual System after Repetitive Mild Traumatic Brain Injury. [PDF]

PLoS ONE, 2016
Repetitive mild traumatic brain injury (r-mTBI) results in neuropathological and biochemical consequences in the human visual system. Using a recently developed mouse model of r-mTBI, with control mice receiving repetitive anesthesia alone (r-sham) we ...
Radouil Tzekov, Clint Dawson, Megan Orlando, Benoit Mouzon, Jon Reed, James Evans, Gogce Crynen, Michael Mullan, Fiona Crawford   +8 more
doaj   +1 more source

Advances in stem cell therapy for sensory nerve injury

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Sensory nerves belong to the afferent nerve part of the peripheral nervous system. Their role is to accept the stimuli inside and outside the body and transmit them to the center nerve system to form sensations or reflexes.
CHEN Huidong, ZHANG Yunlong, ZHANG Zhijian, HUA Qingquan   +3 more
doaj   +1 more source

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

The structural and functional integrity of peripheral nerves depends on the glial-derived signal desert hedgehog [PDF]

, 2006
We show that desert hedgehog ( dhh), a signaling molecule expressed by Schwann cells, is essential for the structural and functional integrity of the peripheral nerve.
Jessen, KR, Meier, C, Mirsky, R, Sahni, V, Sharghi-Namini, S, Turmaine, M, Umehara, F   +6 more
core  

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source