Results 51 to 60 of about 2,682,635 (296)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

An Anatomical Study of Median Nerve Branches for Distal Nerve Transfer in Isolated Anterior Interosseous Nerve Syndrome. [PDF]

J Hand Surg Glob Online
Purpose: Isolated anterior interosseous nerve (AIN) syndrome is a forearm compression neuropathy. A viable treatment for the syndrome is distal nerve transfer. However, the option of a donor nerve branch from the median nerve remains debated.
Utrapat K, Khusritheppratan N, Vilai P, Kerdput V, Pradidarcheep W.   +4 more
europepmc   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Novel Uses of Nerve Transfers [PDF]

Neurotherapeutics, 2019
Nerve transfer surgery involves using a working, functional nerve with an expendable or duplicated function as a donor to supply axons and restore function to an injured recipient nerve. Nerve transfers were originally popularized for the restoration of motor function in patients with peripheral nerve injuries.
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Changes in Electrical Activity of the Masseter Muscle and Masticatory Force after the Use of the Masseter Nerve as Donor in Facial Reanimation Surgery

Indian Journal of Plastic Surgery, 2020
Introduction The masseter nerve has been used as a donor nerve for facial reanimation procedures due to the multiple advantages it offers; it has been generally considered that sacrifice of the masseter nerve does not alter the masticatory apparatus ...
Jose E. Telich-Tarriba, Alejandro Orihuela-Rodríguez, Adriana de Lourdes Rivera-Priego, Fernando Ángeles-Medina, Julio Morales-González, Ignacio Mora-Magaña, Adriana Fentanes-Vera, Damian Palafox, Alexander Cárdenas-Mejía   +8 more
doaj   +1 more source

Anatomical considerations for nerve transfer in axillary nerve injury

Scientific Reports, 2023
Abstract This study investigated the anatomical details of the axillary and radial nerves in 50 upper limbs from 29 adult formalin-embalmed cadavers, and 10 fresh upper limbs. The focus was on understanding the course, division, and ramifications of these nerves to improve treatment of shoulder dysfunction caused by axillary nerve damage.
Soo-Jung Kim, Jong-Ho Bang, Hee-Jun Yang, Seong-Hwan Moon, Yun-Rak Choi, Hye-Yeon Lee   +5 more
openaire   +3 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Spinal Accessory Nerve to Suprascapular Nerve Transfer by Dorsal Approach for Shoulder Reanimation in Cases of Brachial Plexus Injuries: Surgical Technique

Indian Journal of Plastic Surgery
Distal nerve transfers are frequently used for the treatment of patients having brachial plexus injuries. Spinal accessory nerve to suprascapular nerve transfer by dorsal approach is advantageous since it brings the site of neurotization closer to the ...
Vinita Puri, Raghav Shrotriya, Venkateshwaran N.   +2 more
doaj   +1 more source

Early Masseter to Facial Nerve Transfer May Improve Smile Excursion in Facial Paralysis

Plastic and Reconstructive Surgery, Global Open, 2018
Background:. Masseter-to-facial nerve transfer has been shown to be an effective and safe treatment option in patients with acute and subacute facial palsy.
Shuhao Zhang, MD, Austin Hembd, MD, Christina W. Ching, MD, Philip Tolley, MS, Shai M. Rozen, MD   +4 more
doaj   +1 more source