A Review of Nervonic Acid Production in Plants: Prospects for the Genetic Engineering of High Nervonic Acid Cultivars Plants [PDF]
Frontiers in Plant Science, 2021 Nervonic acid (NA) is a very-long-chain monounsaturated fatty acid that plays crucial roles in brain development and has attracted widespread research interest.
Fang Liu +5 more
doaj +5 more sources
Lipase-Catalyzed Preparation and Optimization of Structured Phosphatidylcholine Containing Nervonic Acid [PDF]
MoleculesThis study investigated the incorporation of nervonic acid into the chemical structure of phosphatidylcholine via a lipase-catalyzed acidolysis reaction to obtain a functional phospholipid.
Xun Ang +4 more
doaj +4 more sources
Naturally Occurring Nervonic Acid Ester Improves Myelin Synthesis by Human Oligodendrocytes [PDF]
Cells, 2019 The dysfunction of oligodendrocytes (OLs) is regarded as one of the major causes of inefficient remyelination in multiple sclerosis, resulting gradually in disease progression.
Natalia Lewkowicz +8 more
doaj +5 more sources
High-level production of nervonic acid in the oleaginous yeast Yarrowia lipolytica by systematic metabolic engineering [PDF]
Communications Biology, 2023 Nervonic acid benefits the treatment of neurological diseases and the health of brain. In this study, we employed the oleaginous yeast Yarrowia lipolytica to overproduce nervonic acid oil by systematic metabolic engineering.
Hang Su +11 more
doaj +2 more sources
De novo synthesis of nervonic acid and optimization of metabolic regulation by Yarrowia lipolytica [PDF]
Bioresources and Bioprocessing, 2023 Nervonic acid, a natural fatty acid compound and also a core component of nerve fibers and nerve cells, has been widely used to prevent and treat related diseases of the brain nervous system.
Xin-Ru Zhao +6 more
doaj +2 more sources
Nervonic acid level in cerebrospinal fluid is a candidate biomarker for depressive and manic symptoms: A pilot study [PDF]
Brain and Behavior, 2021 Objective Our previous metabolomics study showed that the plasma nervonic acid levels were higher in patients with major depressive disorder (MDD) than those in healthy controls and patients with bipolar disorder (BD).
Yuki Kageyama +6 more
doaj +2 more sources
Germplasm resources of three wood plant species enriched with nervonic acid. [PDF]
Plant Divers, 2022 Nervonic acid (NA) is a very-long-chain monounsaturated fatty acid with pharmaceutical and nutraceutical functions that plays an important role in treating several neurological disorders. One major source of NA is plant seed oil. Here we report fatty acid profiles of seeds and germplasm diversity of six plant species, including three woody plants with ...
He X +6 more
europepmc +4 more sources
Fecal Nervonic Acid as a Biomarker for Diagnosing and Monitoring Inflammatory Bowel Disease [PDF]
BiomedicinesBackground/Objectives: Inflammatory bowel disease (IBD) is a chronic immune-mediated pathology associated with the dysregulation of lipid metabolism. The administration of nervonic acid, a very long-chain fatty acid, has been shown to improve colonic ...
Claudia Kunst +9 more
doaj +2 more sources
Study on the Extraction of Nervonic Acid from the Oil of Xanthoceras sorbifolium Bunge Seeds [PDF]
FoodsSeven fatty acids were detected by GC-MS in Xanthoceras sorbifolium Bunge seed oil extracted at different temperatures, including Palmitic acid C16:0, Stearic acid C18:0, Oleic acid C18:1, Eicosenoic acid C20:1, Docosenoic acid C22:1, Tetracosenoic acid ...
Hui Gao +9 more
doaj +2 more sources
The Acer truncatum genome provides insights into nervonic acid biosynthesis. [PDF]
Plant J, 2020 SUMMARYAcer truncatum (purpleblow maple) is a woody tree species that produces seeds with high levels of valuable fatty acids (especially nervonic acid). However, the lack of a complete genome sequence has limited both basic and applied research on A. truncatum.
Ma Q +14 more
europepmc +4 more sources