Nervonic acid limits weight gain in a mouse model of diet-induced obesity. [PDF]
FASEB J, 2020 Abstract Lipid perturbations contribute to detrimental outcomes in obesity. We previously demonstrated that nervonic acid, a C24:1 ω‐9 fatty acid, predominantly acylated to sphingolipids, including ceramides, are selectively reduced in a mouse model of obesity.
Keppley LJW +6 more
europepmc +4 more sources
Biosynthesis of nervonic acid and its homologues from carboxyl-labeled oleic acid*
Journal of Lipid Research, 1963 An emulsion of carboxyl-labeled potassium oleate was injected directly into the brains of a group of rats, and 24 hr later the rats were sacrificed. The brain sphingolipids were isolated, and from these, the individual normal unsaturated acids. The major
Yasuo Kishimoto, Norman S. Radin
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Decrease in the level of nervonic acid and increased gamma linolenic acid in the plasma of women with polycystic ovary syndrome after a three-month low-glycaemic index and caloric reduction diet [PDF]
Open Life Sciences, 2019 The aetiology of polycystic ovary syndrome (PCOS) remains uncertain and thus dedicated studies are still of much importance. Patients in this group are at high risk for metabolic syndrome, diabetes and ischemic heart disease.
Szczuko Małgorzata +4 more
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Free Fatty Acids Correlate with the Interleukin-1 β and Interleukin-1 Receptor Antagonist in the Early Subacute Phase of Stroke [PDF]
BiomoleculesInflammation contributes to the pathogenesis of ischaemic stroke both as a long-term causal factor and through the inflammatory cascade in acute stroke.
Dariusz Kotlega +5 more
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Nervonic acid alleviates stroke and its associated poststroke depression behaviors
hLifeNervonic acid (NA) is an important long-chain monounsaturated fatty acid found in mammalian nervous tissue. It has recently garnered research attention due to its therapeutic potential in treating psychiatric and neurodegenerative disorders.
Fengrong Zhang +9 more
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Research Progress of Nervonic Acid Biosynthesis
Journal of Oleo Science, 2023 Nervonic acid (NA) is a very-long-chain monounsaturated fatty acid with great application values. It plays a vital role in the development of brain nervous system and the treatment of neurological diseases, so it has attracted much attention from all walks of life.
Cheng Ling +4 more
openaire +2 more sources
Zhongguo youzhi, 2022 神经酸是大脑神经细胞和神经组织的核心成分，与大脑发育密切相关。为促进神经酸的高产和相关产品的规模化开发和应用，对神经酸的来源、提取分离工艺及生理功能进行了综述。神经酸存在于多种动植物及微生物中，提取分离工艺包括低温结晶法、超临界CO2萃取法、尿素包合法、分子蒸馏法等，具有治疗脑部疾病、中枢神经系统脱髓鞘疾病、心脑血管疾病及增强免疫力等生理功能。为获取丰富且高纯度的神经酸，除选育高产神经酸植物品种外，还可以利用基因工程构建高产神经酸转基因植物。此外，在后续研究中可将传统技术与先进技术相结合提取分离神经酸。
王菊花1，许佳敏1，佟祎鑫1，马赛买1，白万明2，白小勇2，孔维宝1 WANG Juhua1, XU Jiamin1, TONG Yixin1, MA Saimai1, BAI Wanming2, BAI Xiaoyong2, KONG Weibao1
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Microbiological assessment, nutritional characterization and phenolic compounds of bee pollen from Mellipona mandacaia Smith, 1983 [PDF]
, 2015 This study aims to assess the microbiological parameters and the chemical composition of 21 samples of stingless bee pollen (Melipona mandacaia) from two regions of Bahia, Brazil (João Dourado and Uibaí), with particular emphasis on the nutritional value,
Carvalho, Carlos Alfredo Lopes de +5 more
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Zhongguo youzhi, 2023 为促进辣木籽油中神经酸的开发利用，以辣木籽为原料，采用低温压榨法、超临界CO2萃取法、索氏抽提法提取辣木籽油，筛选合适的提油方法，再以辣木籽油为原料制备混合脂肪酸，通过低温结晶法纯化辣木籽油中的神经酸，通过单因素实验和响应面实验优化神经酸的纯化工艺。结果表明：低温压榨法提取的辣木籽原油中神经酸含量较高，达到0.88%；低温结晶法纯化辣木籽油中神经酸的最优工艺条件为料液比（混合脂肪酸与结晶溶剂质量体积比）1∶ 4.2、结晶温度-21 ℃、结晶时间2.3 h，该条件下所得产品中神经酸含量为(5.36±0 ...
宋贤娟1，黄志远1，许波1，普岳红1,2，黄艾祥1，王雪峰1,2 SONG Xianjuan1，HUANG Zhiyuan1，XU Bo1，PU Yuehong1,2， HUANG Aixiang1，WANG Xuefeng1,2
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Oil Content and Nervonic Acid Content of Acer truncatum Seeds from 14 Regions in China
Horticultural Plant Journal, 2019 Acer truncatum is considered a promising species as a raw material to produce nervonic acid (NA). The goal of this study was to explore the variation of oil content and nervonic acid content of 138 accessions native to 14 regions in China as well as ...
Qian Qiao +6 more
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