Results 81 to 90 of about 2,663,952 (341)

Drug therapy for chronic musculoskeletal pain syndromes: the concept of adjuvant analgesics and the prospect of its implementation

Неврология, нейропсихиатрия, психосоматика, 2020
Treatment for pain syndromes is one of the most relevant areas of modern medicine, which is of high social, economic and, individual importance. One of the most difficult questions is therapy for chronic pain (CP).
S. A. Zhivolupov, I. V. Litvinenko, I. N. Samartsev, N. A. Rashidov, A. Yu. Kravchuk, A. N. Barinov   +5 more
doaj   +1 more source

Effect of Acupuncture on the p38 Signaling Pathway in Several Nervous System Diseases: A Systematic Review

International Journal of Molecular Sciences, 2020
Acupuncture is clinically used to treat various diseases and exerts positive local and systemic effects in several nervous system diseases. Advanced molecular and clinical studies have continually attempted to decipher the mechanisms underlying these ...
Tzu-Hsuan Wei, C. Hsieh
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Craniospinal irradiation for respiratory failure secondary to central nervous system Erdheim-Chester disease [PDF]

, 2022
Rahul N. Prasad, Peter Kobalka, Haley K. Perlow, Daniel M. Prevedello, Dukagjin Blakaj, Raju R. Raval, Joshua D. Palmer   +6 more
openalex   +1 more source

Role of Exosomes in Central Nervous System Diseases

Frontiers in Molecular Neuroscience, 2019
There are many types of intercellular communication, and extracellular vesicles are one of the important forms of this. They are released by a variety of cell types, are heterogeneous, and can roughly be divided into microvesicles and exosomes according ...
Wanying Liu, Xiaodan Bai, Ao Zhang, Juanjuan Huang, Shixin Xu, Junping Zhang   +5 more
semanticscholar   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

The central vein sign in the diagnosis of multiple sclerosis

Неврология, нейропсихиатрия, психосоматика
Objective: to determine the specificity and sensitivity of the central vein sign (CVS) for the diagnosis of multiple sclerosis (MS). Material and methods. We analyzed 76 patients.
Sh. R. Nabiev, S. A. Dzhukkaeva, M. Sh. Asvedov, O. N. Voskresenskaya   +3 more
doaj   +1 more source

The Quality of Life in Patients After Surgical Treatment of a Lumbar Disc Herniation — a Preliminary Study

Pielęgniarstwo Neurologiczne i Neurochirurgiczne, 2017
Introduction. Herniated intervertebral disc is a disease that is one of the main causes of sciatica and severe, sharp back pain and usually concerns adults aged 35 to 50 years. Aim.
Joanna Rosińczuk, Aleksandra Pytel, Małgorzata Miksiewicz, Aleksandra Kołtuniuk   +3 more
doaj   +1 more source

Bioprinting Neural Systems to Model Central Nervous System Diseases

Advanced Functional Materials, 2020
To date, pharmaceutical progresses in central nervous system (CNS) diseases are clearly hampered by the lack of suitable disease models. Indeed, animal models do not faithfully represent human neurodegenerative processes and human in vitro 2D cell ...
Boning Qiu, Nils Bessler, Kianti P Figler, Maj-Britt Buchholz, A. Rios, J. Malda, R. Levato, Massimiliano Caiazzo   +7 more
semanticscholar   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source