Results 41 to 50 of about 512,149 (288)
Quantum simulation of classical thermal states
, 2011 We establish a connection between ground states of local quantum Hamiltonians and thermal states of classical spin systems. For any discrete classical statistical mechanical model in any spatial dimension, we find an associated quantum state such that ...
Dür, W., Nest, M. Van den
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Letters in Mathematical Physics, 2006 We identify the obstructions for T-dualizing the boundary WZW model and make explicit how they depend on the geometry of branes. In particular, the obstructions disappear for certain brane configurations associated to non-regular elements of the Cartan torus.
openaire +3 more sources
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Ultrafast hot carrier transfer in WS2/graphene large area heterostructures
npj 2D Materials and Applications, 2022 Charge transfer processes in two-dimensional van der Waals heterostructures enable upconversion of low energy photons and efficient charge carriers extraction.
Chiara Trovatello +8 more
doaj +1 more source
Journal of Chemical Theory and Computation, 2019 We report an embarrassingly parallel method for the evaluation of thermodynaproperties over an energy landscape exhibiting broken ergodicity, nested basin-samp(NBS). We also introduce the No Galilean U-Turn Sampler (NoGUTS), a new sapling scheme based on the No U-Turn Sampler (NUTS) introduced by Hoffman Gelman (2014) that works with the Galilean Monte
Matthew Griffiths, David J. Wales
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The power of a critical heat engine
Nature Communications, 2016 The second law of thermodynamics says that the efficiency of a heat engine is limited by the Carnot efficiency. Here, the authors use finite-size-scaling theory to investigate whether this ultimate limit can be achieved at finite power using quantum Otto
Michele Campisi, Rosario Fazio
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Nanomaterials, 2021 In recent years, bimetallic nanocrystals have attracted great interest from many researchers. Bimetallic nanocrystals are expected to exhibit improved physical and chemical properties due to the synergistic effect between the two metals, not just a ...
Gaojie Li +6 more
doaj +1 more source
The Future of Dams Project: Governance Statement [PDF]
, 2017 This governance statement sets out shared principles to guide our work and our relationships with each other on the New England Sustainability Consortium’s Future of Dams project.
NEST - New England Sustainability Consortium
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