Results 51 to 60 of about 41,897 (208)

Clinicopathological and prognostic significance of nestin expression in patients with breast cancer: a systematic review and meta-analysis

Cancer Cell International, 2020
Background Nestin has been revealed to promote tumorigenesis, progression, metastasis, and angiogenesis of breast cancer. Although the prognostic and clinicopathological impact of nestin expression on breast cancer patients has been assessed in several ...
Xinyi Zhang, Changsheng Xing, Wenting Guan, Lang Chen, Kai Guo, Anze Yu, Kai Xie   +6 more
doaj   +1 more source

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

Nestin expression in induced MSC.

, 2019
Nestin relative expression in AT-MSC, BM-MSC, SD-MSC and UC-MSC after neural induction. (A, B, C, D) Immunocytochemistry analysis of nestin at day 5 of neural induction; (A) AT-MSC, (B) BM-MSC, (C) SD-MSC, (D) UC-MSC. Nestin marker expression (green) and
José J. Minguell (6443933), Rodrigo Mardones (6443930), Ana Maria Vega-Letter (6443936), Pablo Caviedes (1669006), Claudio M. Jofre (6443939), Daniela N. Urrutia (6443927)   +5 more
core   +1 more source

Nestin expression in pancreatic exocrine cell lineages

, 2004
Expression of nestin has been suggested to be a characteristic of pancreatic islet stem cells. To determine whether nestin is indeed expressed in such putative cells during embryonic development, or in the adult pancreas after injury, we performed a cell
Alexandra Delacour, Trumpp, Andreas, Trumpp, A., Virginie Nepote, Delacour, Alexandra, Andreas Trumpp, Pedro Luis Herrera, Herrera, P. L., Delacour, A., Nepote, V., Nepote, Virginie, Herrera, Pedro Luis   +11 more
core   +2 more sources

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Bone-derived Nestin-positive mesenchymal stem cells improve cardiac function via recruiting cardiac endothelial cells after myocardial infarction

Stem Cell Research & Therapy, 2019
Background Bone-derived mesenchymal stem cell (BMSC) transplantation has been reported to be effective for the treatment of ischemic heart disease, but whether BMSCs are the optimal cell type remains under debate. Increasing numbers of studies have shown
Dihan Lu, Yan Liao, Shuang-Hua Zhu, Qiao-Chao Chen, Dong-Mei Xie, Jian-Jun Liao, Xia Feng, Mei Hua Jiang, Wen He   +8 more
doaj   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

Nestin overexpression promotes endothelial proliferation.

, 2019
(A) Co-immunofluorescence staining of PCNA and Nestin reveals multiple Nestin+ PCNA+ cells (arrow) in the intima of a concentric lesion from a PAH patient.
Daniela Farkas (334698), Rebecca Moncayo (6475607), Kaivalya Dandamudi (6475610), Schuyler Hultman (6475604), Carlyne D. Cool (526869), Aneel R. Bhagwani (6475601), Arsema K. Zadu (6475613), Laszlo Farkas (91352)   +7 more
core   +1 more source

Mitochondria‐Localized Nestin Protects Mesenchymal Stem Cells from Senescence by Maintaining Cristae Structure and Function

Advanced Science
Nestin, a well‐characterized intermediate filament protein expressed in stem cells, is increasingly recognized for its non‐canonical roles in diverse subcellular compartments.
Hainan Chen, Jinsi Chen, Li Huang, Xingqiang Lai, Kai Xia, Qiying Lu, Bingbing Xie, Yinong Huang, Yuan Qiu, Tao Wang, Jianqi Feng, Yuanjun Guan, Siyao Che, Jiancheng Wang, Andy Peng Xiang   +14 more
doaj   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source