Results 61 to 70 of about 80,828 (221)
Acid Base Accounting of Mine Waste
, 2014 There has been a growing demand for environmental assessment of a mining site in the recent years. It has become very important that field and laboratory tests are to be performed to study the overburden and resulting mine tailings characteristics.
Singh, Indrajeet, Nag, Rahul Anand
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Investigation into the sustainable use of mine waste to treat or prevent acid mine drainage
, 2023 MEng (Chemical Engineering), North-West University, Potchefstroom CampusMine waste rock or tailings generate acid when sulphide minerals such as Pyrite (FeS2) oxidise in the presents of oxygen and water.
Van Wyk, Naythan
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
A mineralogical approach to evaluating laboratory scale acid rock drainage characterisation tests
, 2016 Effective management of the risks associated with acid rock drainage (ARD) requires the ability to identify material with a potential to generate ARD reliably.
Franzidis, J-P +4 more
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
, 2012 textThis thesis examines the response of air pollutant emissions, water use and carbon emissions from electric power supply systems (electrical grids) to market forces and natural and human disruptions.
Alhajeri, Nawaf Salem
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Comparison of static and mineralogical ARD prediction methods in the Nordic environment
, 2018 Acid rock drainage (ARD) is a major problem related to the management of mining wastes, especially concerning deposits containing sulphide minerals.
Karlsson, Teemu, +3 more
core +1 more source