Results 61 to 70 of about 57,310 (212)

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Association between Dietary Acid Load and Depression, Anxiety, and Stress: A Systematic Review [PDF]

International Journal of Nutrition Sciences
Background: Several studies have suggested a potential association between diet and mental disorders. This systematical review investigated the association between dietary acid load (DAL) and mental health outcomes such as depression, anxiety, and stress.
Mohammad Javad Zare, Samaneh Madani, Afsane Ahmadi   +2 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Dietary acid load and mortality in the Japan Multi-Institutional Collaborative Cohort Study

Scientific Reports
The impact of diet on the body acid-base balance may be related to the risk of various chronic diseases. This prospective cohort study examined the relationships between the dietary acid load and all-cause and cause-specific mortalities in a large ...
Taichi Unohara, Takeshi Watanabe, Kokichi Arisawa, Akari Matsuura, Kahori Kita, Yuka Torii, Masashi Ishizu, Sakurako Katsuura-Kamano, Tien Van Nguyen, Jun Otonari, Hiroaki Ikezaki, Keitaro Tanaka, Chisato Shimanoe, Mako Nagayoshi, Yoko Kubo, Takashi Matsunaga, Rieko Okada, Isao Oze, Hidemi Ito, Nobuaki Michihata, Yohko Nakamura, Shiroh Tanoue, Chihaya Koriyama, Sadao Suzuki, Takeshi Nishiyama, Teruhide Koyama, Etsuko Ozaki, Kiyonori Kuriki, Naoyuki Takashima, Keiko Kondo, Takashi Tamura, Keitaro Matsuo   +31 more
doaj   +1 more source

Is the acid load of the diet related to esophageal cancer? A case-control study

Clinical Nutrition Open Science
Summary: Background: Esophageal adenocarcinoma (EAC) is a prevalent type of cancer both globallyand in the northern regions of Iran. The relationship between dietary acid load (DAL) and EAC is not well established.
Omid Nikpayam, Parmis Mirzaei, Golbon Sohrab, Amirmahdi Najafi, Reza Eghdam Zamiri, Alireza Ostadrahimi   +5 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

The Impact of Dietary Acid Load (DAL) on Kidney Function with Stage 4–5 Chronic Kidney Disease: A Cross-Sectional Study in Padang, Indonesia

NAJFNR
Background: Chronic Kidney Disease (CKD) is characterized by a progressive and irreversible decline in glomerular filtration rate (GFR), accompanied by disruptions in acid–base homeostasis, both of which may be exacerbated by an elevated dietary acid ...
Faza Yasira Rusdi, Harnavi Harun, Aya Yuriestia Arifin   +2 more
doaj   +2 more sources

Relationship between dietary acid-base load and non-insulin-based resistance measures in patients with chronic kidney disease

Frontiers in Endocrinology
This study explored the associations between triglyceride glucose (TyG), TyG with body mass index (TyG-BMI), triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio, and metabolic score for insulin resistance (METS-IR) and the effects of ...
Hui Huang, Hui Huang, Qian Wang, Ruimin Zhang, Fang Liu, Fang Liu, Yue Niu, Yayong Luo, Junqian Wang, Junqian Wang, Shuang Li, Zhengchun Tang, Zhengchun Tang, Xueying Cao, Xiaolong Wang, Jian Yang, Sha Luo, Weizhu Deng, Weiguang Zhang, Ying Zheng, Yong Wang, Li Zhang, Guangyan Cai, Xiangmei Chen, Xiangmei Chen, Xiangmei Chen, Zheyi Dong   +26 more
doaj   +1 more source