Results 71 to 80 of about 57,310 (212)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Association between dietary acid load with weight status, dietray quality index (DQI), mean adequacy ratio and energy density among women

مجله دانشگاه علوم پزشکی گرگان, 2019
Background and Objective: Dietary acid load affects acid–base homeostasis, which may be associated with overweight and obesity as well as dietary quality index international (DQI-I), mean adequacy ratio (MAR), energy density (ED).
Somaye Fatahi, Mostafa Qorbani, Leila Azadbakht   +2 more
doaj  

Correlation between dietary acid–base load and chronic kidney disease patients with type 2 diabetes mellitus

Frontiers in Nutrition
ObjectiveThis study aimed to investigate the effect of dietary acid-base load on patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM).DesignA total of 300 patients with CKD were enrolled and divided into three groups according ...
Hui Huang, Hui Huang, Qian Wang, Ruimin Zhang, Ruimin Zhang, Fang Liu, Fang Liu, Yue Niu, Yayong Luo, Shuang Li, Tao Li, Zhengchun Tang, Zhengchun Tang, Xiaolong Wang, Jian Yang, Yong Wang, Li Zhang, Sha Luo, Weiguang Zhang, Ying Zheng, Weizhu Deng, Guangyan Cai, Xiangmei Chen, Xiangmei Chen, Xiangmei Chen, Zheyi Dong   +25 more
doaj   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Association of dietary acid load with inflammatory markers, oxidative stress, and clinical features in patients with knee osteoarthritis

Scientific Reports
Knee osteoarthritis (KOA) is a prevalent chronic condition characterized by inflammation and oxidative stress, particularly in individuals over 40. Dietary factors, specifically dietary acid load (DAL), may influence these pathological processes. However,
Jalal Moludi, Akram Rahimi, Shaimaa A. Qaisar, Soudabeh Hamedi-Shahraki, Farshad Amirkhizi   +4 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

The association between dietary acid load and odds of prostate cancer: a case-control study

Journal of Health, Population and Nutrition
Background and objective Conflicting results exist regarding the associations between dietary acid load (DAL) and cancer risk. This study aimed to investigate the association between DAL and the odds of prostate cancer (PC) in the Iranian population ...
Sanaz Mehranfar, Yahya Jalilpiran, Haleh Rahimi, Alireza Jafari, Leila Setayesh, Cain C. T. Clark, Shiva Faghih   +6 more
doaj   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Dietary acid load significantly predicts 10-years survival in patients underwent coronary artery bypass grafting (CABG) surgery.

PLoS ONE, 2019
BackgroundsNumerous studies have revealed the role of dietary acid load as a potential risk factor for cardiovascular events and blood pressure. However, its role in predicting the mortality rate in patients underwent coronary artery bypass grafting ...
Mahdieh Abbasalizad Farhangi, Mahdi Vajdi, Mahdi Najafi   +2 more
doaj   +1 more source