NetB, a New Toxin That Is Associated with Avian Necrotic Enteritis Caused by Clostridium perfringens [PDF]
PLoS Pathogens, 2008 For over 30 years a phospholipase C enzyme called alpha-toxin was thought to be the key virulence factor in necrotic enteritis caused by Clostridium perfringens.
Paola Vaz, Dane Parker, Robert J. Moore
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NetB, a Pore-Forming Toxin from Necrotic Enteritis Strains of Clostridium perfringens [PDF]
Toxins, 2010 The Clostridium perfringens necrotic enteritis B-like toxin (NetB) is a recently discovered member of the β-barrel pore-forming toxin family and is produced by a subset of avian C. perfringens type A strains.
Robert J. Moore +2 more
exaly +6 more sources
Molecular detection and sequencing of the NetB toxin Gene of clostridium perfringens and evaluation of its pathogenicity in broiler chicken [PDF]
Poultry ScienceClostridium perfringens is the primary cause of necrotic enteritis (NE), one of the most economically destructive illnesses in broiler production. The virulence of this pathogen has recently been linked to the NetB toxin gene, a pore-producing cytotoxin ...
Ibrahim Eldaghayes, Ahmed Hassan
exaly +6 more sources
Identification of a Key Residue for Oligomerisation and Pore-Formation of Clostridium perfringens NetB [PDF]
Toxins, 2014 Necrotic enteritis toxin B (NetB) is a β-pore-forming toxin produced by Clostridium perfringens and has been identified as a key virulence factor in the pathogenesis of avian necrotic enteritis, a disease causing significant economic damage to the ...
Richard W Titball +2 more
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First genomic analysis of a Clostridium perfringens strain carrying both the cpe and netB genes and the proposal of an amended toxin-based typing scheme [PDF]
Frontiers in MicrobiologyClostridium perfringens strains are classified into seven toxinotypes (A–G) based on the profiles of the six typing toxin genes. Among these toxins, NetB is known as an important virulence factor for necrotic enteritis in chickens, and its gene, netB, is
Daisuke Takamatsu, Mariko Okamoto
exaly +6 more sources
Distribution of NetB toxin in chickens infected with [PDF]
Poultry ScienceAvian necrotic enteritis (NE) causes significant economic losses to the global poultry industry. Clostridium perfringens NetB toxin is a key virulence factor causing necrotizing enteritis in chickens, but the receptor of the toxin remains unknown, and ...
Xin-yue Kong, Ya-nan Song, Hai-rong Wang
doaj +3 more sources
Recombinant Limosilactobacillus (Lactobacillus) delivering nanobodies against Clostridium perfringens NetB and alpha toxin confers potential protection from necrotic enteritis [PDF]
MicrobiologyOpen, 2022 Necrotic enteritis (NE), caused by Clostridium perfringens, is an intestinal disease with devastating economic losses to the poultry industry. NE is a complex disease and predisposing factors that compromise gut integrity are required to facilitate C ...
Dharanesh Gangaiah +8 more
doaj +4 more sources
Oral and parenteral vaccination of broiler chickens with Recombinant NetB antigen from Clostridium perfringens confers significant protection against necrotic enteritis [PDF]
BMC Veterinary ResearchBackground Necrotic enteritis is a devastating economic disease caused by Clostridium perfringens in poultry. NetB toxin from C. perfringens type G is the major responsible cause of necrotic enteritis.
Mehdi Golchin +1 more
exaly +3 more sources
Molecular epidemiology and PFGE-based genetic diversity of Clostridium perfringens in broiler chickens from Eastern Türkiye [PDF]
BMC Veterinary ResearchBackground Clostridium perfringens is a ubiquitous foodborne and opportunistic anaerobe and a leading cause of necrotic enteritis (NE) in broiler chickens, with implications for animal health, food safety, and public health.
Burcu Karagulle +2 more
doaj +2 more sources
An engineered Escherichia coli-ClyA-NetB outer membrane vesicle delivery system modulates jejunal microbiota in broiler chickens with necrotic enteritis [PDF]
Poultry ScienceNecrotic enteritis (NE), caused by Clostridium perfringens (CP), remains one of the most economically consequential enteric diseases in broiler production, and currently available preventive strategies provide incomplete protection.
Fan Lin, Cheng-En Wu, Wen-Yuan Yang
doaj +2 more sources