Results 111 to 120 of about 16,413 (245)

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

Feature of NETosis in Chronic Granulomatous Disease and Its Impact on Renal Disorder

Frontiers in Bioscience-Landmark
Chronic granulomatous disease (CGD) is an inherited immunodeficiency characterized by impaired phagocytic cells due to mutations in genes encoding the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase enzyme complex, leading to recurrent severe
Tetsuya Abe, Yukihiro Wada, Emiko Takeuchi, Masashi Satoh, Takayuki Imanishi, Makoto Otsu, Tadahiro Suenaga, Yasuo Takeuchi   +7 more
doaj   +1 more source

Multiomics integration reveals NETosis heterogeneity and TLR2 as a prognostic biomarker in pancreatic cancer

npj Precision Oncology
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant neoplasm characterized by a poor prognosis and limited therapeutic strategy. The PDAC tumor microenvironment presents a complex heterogeneity, where neutrophils emerge as the predominant ...
Yifan Fu, Jinxin Tao, Yani Gu, Yueze Liu, J. Qiu, Dan Su, Ruobing Wang, W. Luo, Tao Liu, Feifan Zhang, Taiping Zhang, Yupei Zhao   +11 more
semanticscholar   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

M. Freire Lab. Netosis: NETosis related codes and experiments

Neutrophil Extracellular Traps (NETs) are a crucial host defense mechanism employed by neutrophils in response to various aggregates and contribute to pathology in diverse diseases, from chronic inflammation to sepsis. This protocol details the preparation of stimulated differentiated HL-60 cells with Phorbol 12-myristate 13-acetate followed by the ...
Li, Gavin, Versales, Sara, Guadagnino, Brett, Krishnan, Kavya, Matsuoka, Michele, Jang, Hyesun, Freire, Marcelo   +6 more
openaire   +2 more sources

Auto-amplification and spatial propagation of neutrophil extracellular traps

Communications Biology
The release of cellular DNA as neutrophil extracellular traps (NETs) plays a pivotal role in the immune response to pathogens by physically entrapping and killing microbes.
Pan Deng, Alec Xu, Peter M. Grin, Kerryn Matthews, Simon P. Duffy, Hongshen Ma   +5 more
doaj   +1 more source

Sepsis Induces a Dysregulated Neutrophil Phenotype That Is Associated with Increased Mortality

Mediators of Inflammation, 2018
Background. Neutrophil dysfunction in sepsis has been implicated in the pathogenesis of multiorgan failure; however, the role of neutrophil extracellular traps (NETs) remains uncertain.
Jaimin M. Patel, Elizabeth Sapey, Dhruv Parekh, Aaron Scott, Davinder Dosanjh, Fang Gao, David R. Thickett   +6 more
doaj   +1 more source

Pneumocystis murina promotes inflammasome formation and NETosis during Pneumocystis pneumonia

mBio
Pneumocystis jirovecii pneumonia (PjP) poses a serious risk to individuals with compromised immune systems, such as individuals with HIV/AIDS or undergoing immunosuppressive therapies for cancer or solid organ transplants.
Steven G. Sayson, A. Ashbaugh, Aleksey Porollo, George Smulian, Melanie T. Cushion   +4 more
semanticscholar   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Periodontitis and Inflammatory Bowel Diseases: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review aims to provide a conceptual framework for understanding the mechanistic interplay between periodontitis and IBD, with a particular emphasis on the microbial and immunological crosstalk linking the oral cavity and the gastrointestinal tract.
Ana Paula V. Colombo, Adriana M. de Oliveira, Nobuhiko Kamada, Sho Kitamoto   +3 more
wiley   +1 more source