Results 121 to 130 of about 18,973 (244)

Piezo1 expression in neutrophils regulates shear-induced NETosis

Nature Communications
Neutrophil infiltration and subsequent extracellular trap formation (NETosis) is a contributing factor in sterile inflammation. Furthermore, neutrophil extracellular traps (NETs) are prothrombotic, as they provide a scaffold for platelets and red blood ...
Sara Baratchi, Habiba Danish, Chanly Chheang, Ying Zhou, Angela Huang, Austin Lai, Manijeh Khanmohammadi, Kylie M. Quinn, Khashayar Khoshmanesh, Karlheinz Peter   +9 more
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Farklı yönleriyle NETosis

, 2020
Autoimmune and autoinflammatory diseases have dramatically increased in both developed and developing countries. The etiology of these diseases is complex and developed due to multifactorial causes. It is tought that autoantigens are the basis of systemic autoimmune diseases in organism.
Sürsal, Neslihan, Yıldız, Kader
openaire   +1 more source

TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression

Advanced Science, Volume 13, Issue 7, 3 February 2026.
TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu, Jiabi Liang, Linda Zeng, Shuping Zhong, Xueling Fang, Yating Xu, Yongjian Wu, Xi Huang   +7 more
wiley   +1 more source

Auto-amplification and spatial propagation of neutrophil extracellular traps

Communications Biology
The release of cellular DNA as neutrophil extracellular traps (NETs) plays a pivotal role in the immune response to pathogens by physically entrapping and killing microbes.
Pan Deng, Alec Xu, Peter M. Grin, Kerryn Matthews, Simon P. Duffy, Hongshen Ma   +5 more
doaj   +1 more source

NET and NETosis – new phenomenon in immunology

Postępy Higieny i Medycyny Doświadczalnej, 2012
Neutrophils are one of the first cells of the immune system recruited to the site of infection, representing the host's most effective and numerous front-line defenders. Recently, a novel antimicrobial mechanism of neutrophils has been described: upon activation, they release DNA and a subset of their granule content, forming neutrophil extracellular ...
Natalia, Matoszka, Joanna, Działo, Beata, Tokarz-Deptuła, Wiesław, Deptuła   +3 more
openaire   +2 more sources

Elevator‐Like Hollow Channels in Porous Scaffolds Accelerate Vascularized Bone Regeneration via NETs‐Fibrin‐Mediated Macrophage Recruitment

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study demonstrates that how hollow‐channel scaffolds promote vascularized bone regeneration via an immunomodulatory mechanism. The channel structures facilitate the formation of a neutrophil extracellular traps‐fibrin scaffold that recruits vascular endothelial growth factor A (VEGF‐A)‐secreting M2 macrophages to drive angiogenesis. Combining this
Guifang Wang, Rongpu Liu, Huijing Ma, Shuhan Duan, Guangzheng Yang, LingXi Meng, Yuqin Qiao, Dongqiang Song, Wenjie Zhang   +8 more
wiley   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

The Role of Immune Infiltration and Oxidative Stress in the Progression of Cerebral Cavernous Malformation

Brain and Behavior, Volume 16, Issue 2, February 2026.
Mechanism of rupture hemorrhage in cerebral cavernous malformations. Environmental and immune factors promote the progression of lesions and induce the risk of abnormal formation or rupture of cerebrovascular vessels. Abstract Purpose of Review To review how the immune microenvironment and oxidative stress modulate the initiation, maturation, and ...
Xuesai Zhu, Yizhi Yao, Tengbo Yu, Xiao Xiao   +3 more
wiley   +1 more source

Integrative cross‐tissue and spatially resolved single‐cell profiling uncovers tumour‐educated inflammatory remodelling of tissue‐resident macrophage ecosystem with immunotherapeutic prognostic significance in pan‐cancer

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Pan‐cancer analysis reveals an inflammatory phenotype remodeling of tissue‐resident macrophages (iTRM) in the tumor microenvironment, which is associated with immunosuppression. Tissue‐resident macrophages and monocyte‐derived macrophages exhibit convergent differentiation toward a similar inflammatory phenotype. iTRM‐enriched ecosystems are associated
Weikai Wang, Zibin Chen, Yuhan Huang, Zhihao Hu, Peixin Zhu, Zhuoli Huang, Jingzhi Lv, Ziru Liao, Yuhui Zheng, Chen Wei, Baibing Guan, Yin Zeng, Xinyue Zhu, Yafei Yang, Guibo Li, Xin Jin, Xi Chen, Xiao Yang, Zikun Ma, Jianhua Yin   +19 more
wiley   +1 more source

NETosis-based prognostic model reveals immune modulation in clear cell renal cell carcinoma using single-cell and bulk RNA sequencing

Scientific Reports
Further research is needed to investigate the association between netosis and clear cell renal cell carcinoma (ccRCC). We developed a prognostic framework for netosis using univariate, Lasso, and multivariate Cox regression analyses.
Zijie Yu, Zihao Xu, Xi Zhang, Wenchuan Shao, Da Zhong, Xinghan Yan, Tingfei Jiang, Yichun Wang, Ninghong Song   +8 more
doaj   +1 more source