Results 131 to 140 of about 19,431 (234)

Multi‐Omics Analysis in Autoimmunity: Identification of MicroRNA Regulatory Networks and Cell‐Type‐Specific Dysregulations in Multiple Sclerosis and Type 1 Diabetes

MedComm, Volume 7, Issue 4, April 2026.
This study evaluates the expression of microRNAs (miRNAs) in three distinct immune subsets (CD14+ monocytes, neutrophils, and CD8+ T cells) in multiple sclerosis and type 1 diabetes, reporting the presence of unique alteration patterns. Our integrative multi‐omics analysis suggests that miRNAs play a pivotal role in the differentiation and migration of
Jacopo Ronchi, Roberta Rigolio, Davide Maria Trevisan, Angela Papagna, Angela Stabilini, Martina Gallinaro, Maria Letizia Fusco, Martina Gaia Cogo, Guido Cavaletti, Giovanni Malerba, Manuela Battaglia, Maria Foti   +11 more
wiley   +1 more source

Neutrophil biology [PDF]

, 2015
Neutrophil extracellular traps (NETs) are involved in bacterial killing as well as autoimmunity, because NETs contain proteases, bactericidal peptides, DNA and ribonucleoprotein. NETs are formed via a novel type of cell death called NETosis.
Kobayashi, Yoshiro
core  

Therapeutic Galectin‐3 Apheresis Improves Sepsis Outcomes Through Coordinated Neutrophil Modulation and Endothelial Barrier Preservation: A Translational Study

MedComm, Volume 7, Issue 4, April 2026.
Gal‐3 apheresis reduces neutrophil hyperactivation (CXCL2/CXCL8, MPO, NETs), preserves endothelial barrier function (tight junctions, vWF/VCAM‐1/ICAM‐1), and attenuates PI3K/AKT/HIF‐1α signaling. These coordinated effects significantly improve hemodynamics, reduce pulmonary edema (ELWI), lower vasopressor and fluid requirements, and increase survival ...
Zhongyi Sun, Jiachen Qu, Sheng Peng, Yanan Hu, Amity Eliaz, Glenn M. Chertow, Isaac Eliaz, Zhiyong Peng   +7 more
wiley   +1 more source

NETosis-based prognostic model reveals immune modulation in clear cell renal cell carcinoma using single-cell and bulk RNA sequencing

Scientific Reports
Further research is needed to investigate the association between netosis and clear cell renal cell carcinoma (ccRCC). We developed a prognostic framework for netosis using univariate, Lasso, and multivariate Cox regression analyses.
Zijie Yu, Zihao Xu, Xi Zhang, Wenchuan Shao, Da Zhong, Xinghan Yan, Tingfei Jiang, Yichun Wang, Ninghong Song   +8 more
doaj   +1 more source

Vaspin identified as a DNA‐binding serpin with functional consequences for protease inhibition

The FEBS Journal, Volume 293, Issue 7, Page 2119-2132, April 2026.
Vaspin is a serpin that is expressed in skin, adipose tissue, and liver. It binds to single‐ and double‐stranded DNA with high affinity. This binding is unaffected by mutation of the known heparin‐binding site, accelerates the inhibition of the inflammatory protease KLK7, and may contribute to vaspin's nuclear localization.
Kevin Möhlis, Abibe Useini, Heike Betat, Sonja Bonin, Helen Broghammer, Rima Nuwayhid, Stefan Langer, Mario Mörl, Norbert Sträter, John T. Heiker   +9 more
wiley   +1 more source

Single‐Cell Transcriptomic Analysis of Chemotherapy‐Induced Changes in Osteosarcoma With a Pyroptosis‐Related Gene‐Based Prognostic Model

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Osteosarcoma, the most common primary malignant bone tumour, presents significant treatment challenges due to its complex tumour microenvironment and the development of chemoresistance. This study employs single‐cell transcriptomics to investigate chemotherapy‐induced changes in osteosarcoma at both the cellular and molecular levels.
Tao Jin, Lei Dong, Wang Kai, Ziyang Yu, Guoyong Yu, Weifeng Liu   +5 more
wiley   +1 more source

Scavenging of Isolevuglandins Attenuates Neutrophil Migration and Neutrophil Extracellular Trap Formation in Systemic Lupus Erythematosus

ACR Open Rheumatology
Objective Systemic lupus erythematosus (SLE) is an autoimmune disease that affects numerous organs. Neutrophil extracellular traps (NETs) contribute to sterile inflammation and autoantibody generation in SLE.
Jaya Krishnan, Néstor de laVisitación, Johnson C. Phung, Jonathan M. Williams, Leslie J. Crofford, Matthew Alexander, David M. Patrick, Anna E. Patrick   +7 more
doaj   +1 more source

Cancer Cell‐Derived Large Extracellular Vesicles Promote Venous Thromboembolism by Activating NETosis Through Delivering CYBA

Advanced Science
Venous thromboembolism (VTE) is the second‐leading cause of cancer‐associated mortality. Neutrophil extracellular trap formation (i.e., NETosis) is a crucial process in forming VTE in cancer patients.
Xiangji Li, Yingjiao Ju, Chenjie Xu, Shixiang Ma, Lan Sun, Qingdong Guo, Mingyuan Liu, Yibin Xie, Li Min   +8 more
doaj   +1 more source

A Risk Developing Prominent Hyperphosphatemia Leading to Renal Failure in Cup‐Like Leukemia

eJHaem, Volume 7, Issue 2, April 2026.
Osamu Imataki, Makiko Uemura, Shumpei Uchida, Akihiro Takeuchi   +3 more
wiley   +1 more source

High-mobility group protein B1 derived mutant peptide mB Box-97 inhibits the formation of neutrophil extracellular traps

Frontiers in Immunology
IntroductionNeutrophil Extracellular Traps (NETs) are vital for innate immunity, playing a key role in controlling pathogen and biofilm proliferation. However, excessive NETosis is implicated in autoimmunity, inflammatory and neoplastic diseases, as well
Kunal R. More, Aishwarya Devaraj, Frank H. Robledo-Avila, Santiago Partida-Sanchez, Santiago Partida-Sanchez, Lauren O. Bakaletz, Lauren O. Bakaletz, Steven D. Goodman, Steven D. Goodman   +8 more
doaj   +1 more source