Results 71 to 80 of about 104,683 (267)

A mixed-methods evaluation of transformational change in NHS North East

Health Services and Delivery Research, 2014
Background: The North East Transformation System (NETS) was conceived as an experiment in adopting large-scale transformational change across a NHS region in England.
David J Hunter, Jonathan Erskine, Chris Hicks, Tom McGovern, Adrian Small, Ed Lugsden, Paula Whitty, Ian Nick Steen, Martin Eccles   +8 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Making a "net" for the net

Journal of Open, Flexible and Distance Learning, 2012
The rapid development of open learning has seen a major change in the traditional tertiary student profile. Many new students have come to tertiary education with varying backgrounds that are often limited to less than three years of secondary schooling There has been a major change in the age and background profile of the New Zealand tertiary student ...
Nola Campbell, Russell Yates, Clive McGee   +2 more
openaire   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

DNA-Containing Extracellular Structures of Tumor Cells Inhibit the Formation of Neutrophil Extracellular Traps in vitro

Бюллетень сибирской медицины
Aim. To study the parameters of formed DNA-containing extracellular structures during co-cultivation of neutrophils from healthy donors, HСT116 adenocarcinoma cells and K562 myeloblastoma.Materials and methods.
A. N. Kazimirskii, J. M. Salmasi, G. V. Poryadin, M. I. Panina, A. E. Kim, A. G. Chakhalian, O. O. Turishcheva   +6 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Gas diffusion enhanced electrode with ultrathin superhydrophobic macropore structure for acidic CO2 electroreduction

Nature Communications
Carbon dioxide (CO2) electroreduction reaction (CO2RR) offers a promising strategy for the conversion of CO2 into valuable chemicals and fuels. CO2RR in acidic electrolytes would have various advantages due to the suppression of carbonate formation ...
Mingxu Sun, Jiamin Cheng, Miho Yamauchi
doaj   +1 more source