Citrullinated Histone H3 as a Therapeutic Target for Endotoxic Shock in Mice [PDF]
Frontiers in Immunology, 2020 Sepsis results in millions of deaths every year, with acute lung injury (ALI) being one of the leading causes of mortality in septic patients. As neutrophil extracellular traps (NETs) are abundant in sepsis, neutralizing components of NETs may be a ...
Qiufang Deng +2 more
exaly +4 more sources
Citrullinated Histone H3 Mediates Sepsis-Induced Lung Injury Through Activating Caspase-1 Dependent Inflammasome Pathway [PDF]
Frontiers in Immunology, 2021 Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection that often results in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS).
Yuzi Tian, Zhenyu Wu, Qiufang Deng
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Association between Citrullinated Histone H3 and White Matter Lesions Burden in Patients with Ischemic Stroke [PDF]
Brain Sciences, 2023 Introduction: Neutrophil extracellular traps play a role in the pathophysiology of stroke and are associated with severity and mortality. We aimed to investigate whether the citrullinated histone H3 (CitH3), a biomarker for neutrophil extracellular traps
Xiaohao Zhang +7 more
doaj +2 more sources
A citrullinated histone H3 monoclonal antibody for immune modulation in sepsis [PDF]
Nature CommunicationsCitrullinated histone H3 (CitH3), released from immune cells during early sepsis, drives a vicious cycle of inflammation through excessive NETosis and pyroptosis, causing immune dysfunction and tissue damage.
Wenlu Ouyang +25 more
doaj +2 more sources
Circulating cell free DNA and citrullinated histone H3 as useful biomarkers of NETosis in endometrial cancer [PDF]
Journal of Experimental & Clinical Cancer Research, 2022 Background Cancer mortality is mainly caused by organ failure and thrombotic events. It has been demonstrated that NETosis, a chromatin release mechanism implemented by neutrophils, may contribute to these lethal systemic effects.
Livia Ronchetti +16 more
doaj +2 more sources
Citrullinated histone H3 as a novel prognostic blood marker in patients with advanced cancer. [PDF]
PLoS ONE, 2018 Citrullinated histone H3 (H3Cit) is a central player in the neutrophil release of nuclear chromatin, known as neutrophil extracellular traps (NETs). NETs have been shown to elicit harmful effects on the host, and were recently proposed to promote tumor ...
Charlotte Thålin +9 more
doaj +2 more sources
Presence of neutrophil extracellular traps and citrullinated histone H3 in the bloodstream of critically ill patients. [PDF]
PLoS ONE, 2014 Neutrophil extracellular traps (NETs), a newly identified immune mechanism, are induced by inflammatory stimuli. Modification by citrullination of histone H3 is thought to be involved in the in vitro formation of NETs.
Tomoya Hirose +12 more
doaj +2 more sources
Citrullinated histone H3 and procalcitonin in the diagnosis and predicting the outcome of septic shock [PDF]
BMC Infectious DiseasesSepsis and septic shock stimulate a massive inflammatory response during which neutrophil extracellular traps (NETs) release citrullinated histone H3 (CitH3) into the circulation, leading to tissue damage, coagulopathy, and organ failure.
Nadia Mostafa Mohamed +3 more
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Low serum level of citrullinated histone H3 in patients with dermatomyositis [PDF]
Journal of Clinical Laboratory Analysis, 2023 Wanchan Peng, Siyu Wu
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Neutrophil α-defensin-1 is present in human stroke thrombi and induces NETosis in vitro [PDF]
Frontiers in ImmunologyBackgroundIschemic stroke thrombi contain complex immunothrombotic components, including neutrophil extracellular traps (NETs), which contribute to thrombus stability and resistance to fibrinolysis.
Edward Theodore Littleton +5 more
doaj +2 more sources