Citrullinated histone H3, a marker of extracellular trap formation, is increased in blood of stable asthma patients. [PDF]
Clin Transl Allergy, 2020 Emerging data indicates that extracellular traps (ETs), structures formed by various immune cell types, may contribute to the pathology of noninfectious inflammatory diseases. Histone hypercitrullination is an important step in ETs formation and citrullinated histone H3 (H3cit) is considered a novel and specific biomarker of that process.
Kuczia P +9 more
europepmc +6 more sources
Increased Citrullinated Histone H3 Levels in the Early Post-Resuscitative Period Are Associated with Poor Neurologic Function in Cardiac Arrest Survivors—A Prospective Observational Study [PDF]
Journal of Clinical Medicine, 2019 Lisa-Marie Mauracher +2 more
exaly +2 more sources
Citrullinated Histone H3, a Marker for Neutrophil Extracellular Traps, Is Associated with Poor Prognosis in Cutaneous Squamous Cell Carcinoma Developing in Patients with Recessive Dystrophic Epidermolysis Bullosa [PDF]
CancersHélène Ragot +2 more
exaly +2 more sources
Histone Citrullination Mediates a Protective Role in Endothelium and Modulates Inflammation
Cells, 2022 NETosis is a key host immune process against a pathogenic infection during innate immune activation, consisting of a neutrophil “explosion” and, consequently, NET formation, containing mainly DNA, histones, and other nuclear proteins.
Rebeca Osca-Verdegal +8 more
doaj +1 more source
Relative efficiencies of peptidylarginine deiminase 2 and 4 in generating target sites for anti-citrullinated protein antibodies in fibrinogen, alpha-enolase and histone H3. [PDF]
PLoS ONE, 2018 OBJECTIVE:Peptidylarginine deiminase 2 (PAD2) and PAD4 are expressed in the synovium of rheumatoid arthritis (RA) patients and catalyze citrullination of arginine residues in proteins targeted by anti-citrullinated protein antibodies (ACPAs).
Dres Damgaard +5 more
doaj +1 more source
Fujita Medical Journal, 2023 Objectives: Sepsis is a life-threatening condition characterized by multi-organ dysfunction due to host immune system dysregulation in response to an infection.
Tatsuhiko Harada +7 more
doaj +1 more source
Biomolecules, 2022 Background: Neutrophil extracellular traps’ (NETs’) formation is a mechanism of defense that neutrophils deploy as an alternative to phagocytosis, to constrain the spread of microorganisms.
Laure Morimont +14 more
doaj +1 more source
Identification and Quantitation of Neutrophil Extracellular Traps in Human Tissue Sections
Bio-Protocol, 2021 Neutrophils are one of the first innate immune cells recruited to tissues during inflammation. An important function of neutrophils relies on their ability to release extracellular structures, known as Neutrophil Extracellular Traps or NETs, into their ...
Coraline Radermecker +3 more
doaj +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Citrullination/Methylation Crosstalk on Histone H3 Regulates ER-Target Gene Transcription [PDF]
ACS Chemical Biology, 2017 Posttranslational modifications of histone tails are a key contributor to epigenetic regulation. Histone H3 Arg26 and Lys27 are both modified by multiple enzymes, and their modifications have profound effects on gene expression. Citrullination of H3R26 by PAD2 and methylation of H3K27 by PRC2 have opposing downstream impacts on gene regulation; H3R26 ...
Kathleen W. Clancy +6 more
openaire +3 more sources