Results 11 to 20 of about 3,828 (143)

Quantification of Citrullinated Histone H3 Bound DNA for Detection of Neutrophil Extracellular Traps [PDF]

Cancers, 2020
Formation of neutrophil extracellular traps (NETs) has been associated with multiple pathologies including cancer. While the visualization of NETs by microscopy is a routine technique, their quantification presents a number of challenges. Commonly, as citrullination of histone H3 is required for NET formation, the presence of this modified histone ...
Cindy Lin, Yulia Nefedova, Lin Cindy
exaly   +5 more sources

Citrullinated histone H3: A novel target for the treatment of sepsis [PDF]

Surgery, 2014
We have recently demonstrated that in a rodent model of lipopolysaccharide (LPS)-induced shock, an increase in circulating citrullinated histone H3 (Cit H3) is associated with lethality of sepsis, and treatment with suberoylanilide hydroxamic acid (SAHA), a histone deacetylase (HDAC) inhibitor (HDACI), significantly improves survival. However, the role
Yongqing Li, Zhengcai Liu, Baoling Liu   +2 more
exaly   +5 more sources

Citrullinated histone H3, a biomarker for neutrophil extracellular trap formation, predicts the risk of mortality in patients with cancer [PDF]

British Journal of Haematology, 2019
Summary Prior studies indicate that neutrophil extracellular traps ( NET s) are associated with arterial thromboembolism ( ATE ) and mortality.
Ella Grilz, Lisa-Marie Mauracher, Florian POSCH   +2 more
exaly   +6 more sources

Citrullinated Histone H3 Level as a Novel Biomarker in Pediatric Clinical Sepsis

Indonesian Biomedical Journal, 2021
BACKGROUND: Sepsis is still leading cause of death in critically ill children. Early recognition of sepsis and treatments are needed to reduce its mortality. The use of citrullinated Histone H3 (Cit-H3) as an early sepsis marker and outcome predictor has
Ronald Chandra, Antonius Hocky Pudjiadi, Rismala Dewi   +2 more
doaj   +3 more sources

Citrullinated histone H3 in systemic lupus erythematosus and antiphospholipid syndrome (preliminary results)

Современная ревматология, 2023
Citrullinated histone H3 (CitH3) is a specific marker for NETosis; its role in determining the clinical and laboratory manifestations of systemic lupus erythematosus (SLE) remains to be elucidated.Objective: To evaluate the role of CitH3 in the ...
K. S. Nurbaeva, T. M. Reshetnyak, M. V. Cherkasova, A. M. Lila   +3 more
doaj   +2 more sources

NETs production and citrullinated histone H3 level in children with tuberculosis

Бюллетень сибирской медицины
Aim. To characterize parameters of neutrophil extracellular trap (NET) production in the leukocyte culture and citrullinated histone H3 (citH3) level in peripheral blood to assess the features of NETosis in children with tuberculosis.Materials and ...
D. G. Novikov, A. N. Zolotov, A. V. Indutny, A. V. Mordyk, N. A. Kirichenko, M. A. Romanova, A. O. Ptukhin   +6 more
doaj   +2 more sources

PADI4-mediated citrullination of histone H3 stimulates HIV-1 transcription

Nature Communications
HIV-1 infection establishes a reservoir of long-lived cells with integrated proviral DNA that can persist despite antiretroviral therapy (ART). Certain reservoir cells can be reactivated to reinitiate infection.
Luca Love, Bianca B. Jütte, Birgitta Lindqvist, Hannah Rohdjess, Oscar Kieri, Piotr Nowak, J. Peter Svensson   +6 more
doaj   +4 more sources

Mapping the Substrate Specificity Landscape of PAD2 and PAD4 Enzymes. [PDF]

Chembiochem
Protein citrullination, driven by peptidyl arginine deiminases (PAD2, PAD4), is linked to multiple diseases. Using a combinatorial peptide library and advanced mass spectrometry, we reveal distinct substrate selectivity profiles of PAD2 and PAD4. While PAD2 broadly citrullinates arginine‐containing peptides, PAD4 is highly sequence‐restricted, with ...
Borbély A, Steckel A, Papp D, Pál D, Uray K, Gőz VG, Schlosser G.   +6 more
europepmc   +2 more sources

Association between neutrophil extracellular traps, the Von Willebrand factor axis, and clinical outcome in stable coronary artery disease [PDF]

Frontiers in Cardiovascular Medicine
IntroductionCoronary artery disease (CAD) is the clinical manifestation of atherosclerosis, an inflammatory disorder of the coronary arteries, characterized by endothelial dysfunction, lipid accumulation, immune activation, and formation of ...
Vibeke Bratseth, Kristine M. Kindberg, Kristine M. Kindberg, Ellen M. K. Warlo, Alf-Åge R. Pettersen, Trine B. Opstad, Trine B. Opstad, Miriam S. Langseth, Ragnhild Helseth, Ida G. Lunde, Ida G. Lunde, Ida G. Lunde   +11 more
doaj   +2 more sources

Preclinical characterization of AZD1163, a first-in-class anti-PAD2/4 bispecific antibody for the treatment of rheumatoid arthritis [PDF]

mAbs
Anti-citrullinated protein autoantibodies promote inflammation and joint tissue injury and define a poor prognostic group of patients with rheumatoid arthritis (RA).
Gary P. Sims, Lacie Scaletta, John Andrews, Dorothy A. Sims, Martin Strain, Anna Sigurdardottir, Teneema Kuriakose, Elizabeth England, Lichchavi Rajasinghe, Fanyi Jiang, Ximing Xiong, Frances Neal, Lisa Vinall, Philip Newton, Elin Boger, Chong Kim, Helena Dahlbäck, Susanne Prothon, Jacob Leander, Erika Darrah, Mia Collins, Garry Douglas, Nicholas White, Katie Day, Katherine A. Vousden, Catherine E. Huntington, David Close   +26 more
doaj   +2 more sources