Inhibition of EETosis with an anti-citrullinated histone antibody: a novel therapeutic approach for eosinophilic inflammatory disorders [PDF]
Frontiers in ImmunologyEosinophils are a subset of granulocytes that protect the host against fungal and parasitic infection through secretion of their granular contents. In response to specific stimuli, eosinophils also undergo a type of lytic cell death, referred to as ...
Ueki Shigeharu
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Citrullinated Histone H3 as a Therapeutic Target for Endotoxic Shock in Mice [PDF]
Frontiers in Immunology, 2020 Sepsis results in millions of deaths every year, with acute lung injury (ALI) being one of the leading causes of mortality in septic patients. As neutrophil extracellular traps (NETs) are abundant in sepsis, neutralizing components of NETs may be a ...
Qiufang Deng +2 more
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Citrullinated Histone H3 Mediates Sepsis-Induced Lung Injury Through Activating Caspase-1 Dependent Inflammasome Pathway [PDF]
Frontiers in Immunology, 2021 Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection that often results in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS).
Yuzi Tian, Zhenyu Wu, Qiufang Deng
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Neutrophil stimulation with citrullinated histone H4 slows down calcium influx and reduces NET formation compared with native histone H4. [PDF]
PLoS ONE, 2021 Peptidylarginine deiminase 4 (PAD4) catalyzes posttranslational modification of many target proteins through converting protein arginine or mono-methylarginine to citrulline.
Lai Shi +2 more
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Tocilizumab increases citrullinated histone 3 in non-ST segment elevation myocardial infarction [PDF]
Open Heart, 2021 Objective Beyond reducing inflammation and troponin T (TnT) release, the interleukin-6 receptor antagonist tocilizumab reduces neutrophil counts in patients with non-ST segment elevation myocardial infarction (NSTEMI). It is unclear if this is related to
Thor Ueland +10 more
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A citrullinated histone H3 monoclonal antibody for immune modulation in sepsis [PDF]
Nature CommunicationsCitrullinated histone H3 (CitH3), released from immune cells during early sepsis, drives a vicious cycle of inflammation through excessive NETosis and pyroptosis, causing immune dysfunction and tissue damage.
Wenlu Ouyang +25 more
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Low serum level of citrullinated histone H3 in patients with dermatomyositis [PDF]
Journal of Clinical Laboratory Analysis, 2023 Wanchan Peng, Siyu Wu
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Citrullinated histone H3 as a novel prognostic blood marker in patients with advanced cancer. [PDF]
PLoS ONE, 2018 Citrullinated histone H3 (H3Cit) is a central player in the neutrophil release of nuclear chromatin, known as neutrophil extracellular traps (NETs). NETs have been shown to elicit harmful effects on the host, and were recently proposed to promote tumor ...
Charlotte Thålin +9 more
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Preclinical characterization of AZD1163, a first-in-class anti-PAD2/4 bispecific antibody for the treatment of rheumatoid arthritis [PDF]
mAbsAnti-citrullinated protein autoantibodies promote inflammation and joint tissue injury and define a poor prognostic group of patients with rheumatoid arthritis (RA).
Gary P. Sims +26 more
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Quantification of Citrullinated Histone H3 Bound DNA for Detection of Neutrophil Extracellular Traps [PDF]
Cancers, 2020 Cindy Lin, Yulia Nefedova, Lin Cindy
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