Histone Citrullination Mediates a Protective Role in Endothelium and Modulates Inflammation
Cells, 2022 NETosis is a key host immune process against a pathogenic infection during innate immune activation, consisting of a neutrophil “explosion” and, consequently, NET formation, containing mainly DNA, histones, and other nuclear proteins.
Rebeca Osca-Verdegal +8 more
doaj +5 more sources
Citrullinated histone H3: A novel target for the treatment of sepsis [PDF]
Surgery, 2014 We have recently demonstrated that in a rodent model of lipopolysaccharide (LPS)-induced shock, an increase in circulating citrullinated histone H3 (Cit H3) is associated with lethality of sepsis, and treatment with suberoylanilide hydroxamic acid (SAHA), a histone deacetylase (HDAC) inhibitor (HDACI), significantly improves survival. However, the role
Yongqing Li +2 more
exaly +5 more sources
Increased histone citrullination in juvenile idiopathic arthritis
Frontiers in Medicine, 2022 ObjectivePosttranslational modifications (PTMs) of proteins are crucial for regulating various biological processes. However, protein alteration via PTMs, and consequently, the creation of new epitopes, can induce abnormal autoimmune responses in ...
Zuzana Parackova +5 more
doaj +3 more sources
Citrullinated Histone H3 Level as a Novel Biomarker in Pediatric Clinical Sepsis
Indonesian Biomedical Journal, 2021 BACKGROUND: Sepsis is still leading cause of death in critically ill children. Early recognition of sepsis and treatments are needed to reduce its mortality. The use of citrullinated Histone H3 (Cit-H3) as an early sepsis marker and outcome predictor has
Ronald Chandra +2 more
doaj +3 more sources
NETs production and citrullinated histone H3 level in children with tuberculosis
Бюллетень сибирской медициныAim. To characterize parameters of neutrophil extracellular trap (NET) production in the leukocyte culture and citrullinated histone H3 (citH3) level in peripheral blood to assess the features of NETosis in children with tuberculosis.Materials and ...
D. G. Novikov +6 more
doaj +2 more sources
Histone citrullination: a new target for tumors [PDF]
Molecular Cancer, 2021 AbstractAs the main protein components of chromatin, histones play central roles in gene regulation as spools of winding DNA. Histones are subject to various modifications, including phosphorylation, acetylation, glycosylation, methylation, ubiquitination and citrullination, which affect gene transcription. Histone citrullination, a posttranscriptional
Dongwei Zhu, Yue Zhang, Shengjun Wang
openaire +3 more sources
Citrullinated histone 3 causes endothelial barrier dysfunction. [PDF]
Biochem Biophys Res Commun, 2018 Circulating components of neutrophil extracellular traps (NETs), especially histones, are associated with tissue injury during inflammatory conditions like sepsis. Commonly used as a NET biomarker, citrullinated histone 3 (H3Cit) may also functionally contribute to the NET-associated inflammatory response.
Meegan JE +6 more
europepmc +4 more sources
Citrullinated histone H3, a biomarker for neutrophil extracellular trap formation, predicts the risk of mortality in patients with cancer [PDF]
British Journal of Haematology, 2019 Ella Grilz +2 more
exaly +2 more sources
Citrullinated Histone H3, a Marker for Neutrophil Extracellular Traps, Is Associated with Poor Prognosis in Cutaneous Squamous Cell Carcinoma Developing in Patients with Recessive Dystrophic Epidermolysis Bullosa [PDF]
CancersHélène Ragot +2 more
exaly +2 more sources
Role of PAD Enzymes on Histone Citrullination in Cancer
Medical Journal of Babylon, 2022 Citrullination process is a natural pathway which happened at the time of cell dying, but during removal of these products, PAD enzymes may release causing stimuli to the immune system. This can start a consequence of processes and enhancement of cancer disease.
Noor Mohammed Abdulrahman +1 more
openaire +2 more sources