Results 31 to 40 of about 5,707 (163)
Citrullinated histone H3 and procalcitonin in the diagnosis and predicting the outcome of septic shock. [PDF]
BMC Infect DisAbstract Sepsis and septic shock stimulate a massive inflammatory response during which neutrophil extracellular traps (NETs) release citrullinated histone H3 (CitH3) into the circulation, leading to tissue damage, coagulopathy, and organ failure.
Mohamed NM +3 more
europepmc +2 more sources
Sensing of citrulline modifications in histone peptides by deep cavitand hosts [PDF]
Chemical Communications, 2019 A host–guest fluorescence sensor array can site-selectively sense histone peptide modifications that change only a single atom in the peptide backbone.
Adam D. Gill +5 more
openaire +4 more sources
SMARCAD1 Contributes to the Regulation of Naive Pluripotency by Interacting with Histone Citrullination [PDF]
Cell Reports, 2017 Histone citrullination regulates diverse cellular processes. Here, we report that SMARCAD1 preferentially associates with H3 arginine 26 citrullination (H3R26Cit) peptides present on arrays composed of 384 histone peptides harboring distinct post-transcriptional modifications.
Xiao, Shu +18 more
openaire +4 more sources
Histone citrullination as a novel biomarker and target to inhibit progression of abdominal aortic aneurysms [PDF]
Translational Research, 2021 Neutrophil extracellular traps (NETs) have been implicated in the pathogenesis of abdominal aortic aneurysms (AAAs). This study has addressed the notion that NET components might serve as AAA biomarkers or novel targets of AAA therapy. Thus, parameters of neutrophil activation and NET formation were measured in plasma. Their diagnostic marker value was
Wolf, Eilenberg +32 more
openaire +2 more sources
Arthritis Research & Therapy, 2019 Objective To investigate the expression of peptidylarginine deiminases (PADIs) during macrophage differentiation and its role in inflammatory responses.
Ning-Sheng Lai +5 more
doaj +1 more source
Современная ревматология, 2023 Citrullinated histone H3 (CitH3) is a specific marker for NETosis; its role in determining the clinical and laboratory manifestations of systemic lupus erythematosus (SLE) remains to be elucidated.Objective: To evaluate the role of CitH3 in the ...
K. S. Nurbaeva +3 more
doaj +1 more source
Multifaceted immune dysregulation characterizes individuals at-risk for rheumatoid arthritis
Nature Communications, 2023 Molecular markers of autoimmunity, such as antibodies to citrullinated protein antigens (ACPA), are detectable prior to inflammatory arthritis (IA) in rheumatoid arthritis (RA) and may define a state that is ‘at-risk’ for future RA.
Eddie A. James +29 more
doaj +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Cardiovascular Diabetology, 2019 Background Type 2 diabetes mellitus (T2DM) is associated with a hypercoagulable state and increased neutrophil extracellular traps formation (NETosis).
Agata H. Bryk +7 more
doaj +1 more source
Mapping the Substrate Specificity Landscape of PAD2 and PAD4 Enzymes. [PDF]
ChembiochemProtein citrullination, driven by peptidyl arginine deiminases (PAD2, PAD4), is linked to multiple diseases. Using a combinatorial peptide library and advanced mass spectrometry, we reveal distinct substrate selectivity profiles of PAD2 and PAD4. While PAD2 broadly citrullinates arginine‐containing peptides, PAD4 is highly sequence‐restricted, with ...
Borbély A +6 more
europepmc +2 more sources