Increased Citrullinated Histone H3 Levels in the Early Post-Resuscitative Period Are Associated with Poor Neurologic Function in Cardiac Arrest Survivors—A Prospective Observational Study [PDF]
Journal of Clinical Medicine, 2019 Lisa-Marie Mauracher +2 more
exaly +2 more sources
Relative efficiencies of peptidylarginine deiminase 2 and 4 in generating target sites for anti-citrullinated protein antibodies in fibrinogen, alpha-enolase and histone H3. [PDF]
PLoS ONE, 2018 OBJECTIVE:Peptidylarginine deiminase 2 (PAD2) and PAD4 are expressed in the synovium of rheumatoid arthritis (RA) patients and catalyze citrullination of arginine residues in proteins targeted by anti-citrullinated protein antibodies (ACPAs).
Dres Damgaard +5 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background Human aging is associated with increased risk of thrombosis, but the mechanisms are poorly defined. We hypothesized that aging induces peroxide‐dependent release of neutrophil extracellular traps that contribute to thrombin generation and ...
Rahul Kumar +6 more
doaj +1 more source
Biology, 2021 Numerous studies have shown that cf nDNA significantly rises in stress caused by exercise. However, during nuclear decondensation, released DNA is followed by histones. Histones are also a common disease marker.
Robert Stawski +9 more
doaj +1 more source
Characterization of Autoantigens Targeted by Anti-Citrullinated Protein Antibodies In Vivo: Prominent Role for Epitopes Derived from Histone 4 Proteins. [PDF]
PLoS ONE, 2016 Anti-citrullinated protein antibodies (ACPA) have become an integral part of the clinical definition of rheumatoid arthritis, and are hypothesized to be important in the immunopathogenesis of this autoimmune disease.
Xiaobo Meng +5 more
doaj +1 more source
Biomolecules, 2022 Background: Neutrophil extracellular traps’ (NETs’) formation is a mechanism of defense that neutrophils deploy as an alternative to phagocytosis, to constrain the spread of microorganisms.
Laure Morimont +14 more
doaj +1 more source
Citrullination regulates pluripotency and histone H1 binding to chromatin [PDF]
Nature, 2014 Citrullination is the post-translational conversion of an arginine residue within a protein to the non-coded amino acid citrulline. This modification leads to the loss of a positive charge and reduction in hydrogen-bonding ability. It is carried out by a small family of tissue-specific vertebrate enzymes called peptidylarginine deiminases (PADIs) and ...
Christophorou, Maria A +12 more
openaire +3 more sources
Current Challenges and Limitations in Antibody-Based Detection of Citrullinated Histones [PDF]
Frontiers in Immunology, 2016 Studies on NETosis demand reliable and convenient markers to monitor the progress of this form of cell death. Because a determining step in the release of nuclear chromatin NETs requires the conversion of arginine residues to citrulline residues in histones by peptidylarginine deiminase, citrullinated histones can provide such a marker.
Indira Neeli, Marko Radic
openaire +4 more sources
Progesterone stimulates histone citrullination to increase IGFBP1 expression in uterine cells [PDF]
Reproduction, 2021 Abstract Peptidylarginine deiminases (PAD) enzymes were initially characterized in uteri, but since then little research has examined their function in this tissue. PADs post-translationally convert arginine residues in target proteins to citrulline and are highly expressed in ovine caruncle epithelia and ovine uterine luminal ...
Young, Coleman H. +8 more
openaire +3 more sources
Potential role for PADI-mediated histone citrullination in preimplantation development [PDF]
BMC Developmental Biology, 2012 Abstract Background The peptidylarginine deiminases (PADIs) convert positively charged arginine residues to neutrally charged citrulline on protein substrates in a process that is known as citrullination or deimination.
Kan, Rui +5 more
openaire +3 more sources