Results 31 to 40 of about 3,828 (143)

Citrullination of Histone H3 Interferes with HP1-Mediated Transcriptional Repression

PLoS Genetics, 2012
Multiple Sclerosis (MS) is an autoimmune disease associated with abnormal expression of a subset of cytokines, resulting in inappropriate T-lymphocyte activation and uncontrolled immune response. A key issue in the field is the need to understand why these cytokines are transcriptionally activated in the patients.
Sharma, Priyanka, Azebi, Saliha, England, Patrick, Christensen, Tove, Møller-Larsen, Anné, Petersen, Thor, Batsché, Eric, Muchardt, Christian   +7 more
openaire   +6 more sources

Predictors of neutrophil extracellular traps markers in type 2 diabetes mellitus: associations with a prothrombotic state and hypofibrinolysis

Cardiovascular Diabetology, 2019
Background Type 2 diabetes mellitus (T2DM) is associated with a hypercoagulable state and increased neutrophil extracellular traps formation (NETosis).
Agata H. Bryk, Shannon M. Prior, Krzysztof Plens, Malgorzata Konieczynska, Jerzy Hohendorff, Maciej T. Malecki, Saulius Butenas, Anetta Undas   +7 more
doaj   +1 more source

Characterization of Autoantigens Targeted by Anti-Citrullinated Protein Antibodies In Vivo: Prominent Role for Epitopes Derived from Histone 4 Proteins. [PDF]

PLoS ONE, 2016
Anti-citrullinated protein antibodies (ACPA) have become an integral part of the clinical definition of rheumatoid arthritis, and are hypothesized to be important in the immunopathogenesis of this autoimmune disease.
Xiaobo Meng, Peyman Ezzati, Irene Smolik, Charles N Bernstein, Carol Ann Hitchon, Hani S El-Gabalawy   +5 more
doaj   +1 more source

INCREASED CITRULLINATED HISTONE H3 LEVELS AND ACCELERATED THROMBIN KINETICS IN TRAUMA PATIENTS WHO DEVELOP VENOUS THROMBOEMBOLISM. [PDF]

Shock
ABSTRACT Background: Neutrophil extracellular traps (NETs), and its formation and release, known as NETosis, may play a role in the initiation of thrombin generation (TG) in trauma. The objective of this study was to assess whether trauma patients, who develop symptomatic venous thromboembolism (VTE), have ...
Navarro SM, Thompson RJ, MacArthur TA, Spears GM, Bailey KR, Immermann JM, Yudin N, Dong JF, Kozar RA, Park MS.   +9 more
europepmc   +3 more sources

Neutrophil extracellular traps in stored canine red blood cell units

Journal of Veterinary Internal Medicine, 2020
Background Neutrophil extracellular traps (NETs), webs of DNA and citrullinated histones extruded from activated neutrophils cause transfusion‐related acute lung injury.
Erin R. McQuinn, Stephanie A. Smith, Austin K. Viall, Chong Wang, Dana N. LeVine   +4 more
doaj   +1 more source

The Diagnostic Utility of Natural Killer Cell Subsets in Deep Vein Thrombosis

Vascular Health and Risk Management, 2023
Alshaymaa M Alhabibi,1 Maisa A Wahab,2 Ahmed Khairy Sakr,2 Samar M Abd El-Hamid,1 Mohamed Yahia Zakaria,3 Azza Ali Althoqapy,4 Hanaa Mohammed Eid El Sayed,5 Sammar Ahmed Kasim,5 Hanan F Ibrahim,4 Ola I Saleh,6 Howida A Ahmed,6 Alaa H Sayed,7 Mahmoud ...
Alhabibi AM, Wahab MA, Sakr AK, Abd El-Hamid SM, Zakaria MY, Althoqapy AA, El Sayed HME, Kasim SA, Ibrahim HF, Saleh OI, Ahmed HA, Sayed AH, Lotfy M   +12 more
doaj  

Role of the lipoxin A4 receptor in the development of neutrophil extracellular traps in Leishmania infantum infection

Parasites & Vectors, 2019
Background Neutrophils play an immunomodulatory role through the release of neutrophil extracellular traps (NETs). NETs are released in response to Leishmania infection, but the mechanism of NET extrusion has not been elucidated.
Furong Wei, Wenci Gong, Junyun Wang, Yuetao Yang, Jianxiu Liu, Yanjuan Wang, Jianping Cao   +6 more
doaj   +1 more source

Citrullinated histone H3, a biomarker of neutrophil extracellular trap formation, predicts the risk of venous thromboembolism in cancer patients. [PDF]

J Thromb Haemost, 2018
Essentials Neutrophil extracellular traps (NETs) might play a role in cancer-related coagulopathy. We determined NET biomarkers and followed cancer patients for venous thromboembolism (VTE). We found a constant association with VTE for citrullinated histone H3.
Mauracher LM, Posch F, Martinod K, Grilz E, Däullary T, Hell L, Brostjan C, Zielinski C, Ay C, Wagner DD, Pabinger I, Thaler J.   +11 more
europepmc   +4 more sources

The role of protein arginine deiminase 4-dependent neutrophil extracellular traps formation in ulcerative colitis

Frontiers in Immunology, 2023
BackgroundNeutrophil extracellular traps (NETs) play an important role in the development and progression of ulcerative colitis (UC). Peptidyl arginine deiminase 4 (PAD4) is essential for the formation of NETs via catalyzing histone citrullination.
Ping Wang, Dan Liu, Ziqi Zhou, Fangjun Liu, Yiming Shen, Qi You, Shiping Lu, Jie Wu   +7 more
doaj   +1 more source

Origin of Circulating Free DNA in Sepsis: Analysis of the CLP Mouse Model

Mediators of Inflammation, 2015
Recently, it has been reported that circulating free DNA (cf-DNA) in the blood is increased in various infectious diseases, including sepsis. Moreover, a relationship between cf-DNA and neutrophil extracellular traps (NETs) has been suggested.
Shigeto Hamaguchi, Yukihiro Akeda, Norihisa Yamamoto, Masafumi Seki, Kouji Yamamoto, Kazunori Oishi, Kazunori Tomono   +6 more
doaj   +1 more source