Platelet lysate-derived neuropeptide y influences migration and angiogenesis of human adipose tissue-derived stromal cells [PDF]
, 2018 Neuropeptide Y (NPY), a powerful neurotransmitter of the central nervous system, is a key regulator of angiogenesis and biology of adipose depots. Intriguingly, its peripheral vascular and angiogenic powerful activity is strictly associated to platelets,
Bordin, Antonella +13 more
core +2 more sources
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Frontiers in Pharmacology, 2014 The development of clinical practice recommendations or guidelines for the clinical use of pharmacogenomics data is an essential issue for improving drug therapy, particularly for drugs with high toxicity and/or narrow therapeutic index such as ...
José A G Agúndez +7 more
doaj +1 more source
Animal Ethics and India: Understanding the Connection through the Capabilities Approach [PDF]
, 2017 This paper, unveiling the visionary short-sightedness of animal protection, argues for a just vision towards animals in India. Critically analysing the wide range of animal protections in India, the paper finds that in spite of such protections, animals ...
Chakraborty, Rhyddhi
core +1 more source
Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node
FEBS Open Bio, EarlyView.The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner +6 more
wiley +1 more source
Network pharmacology approach for validation of traditional claims of Ayurvedic medicines [PDF]
Network BiologyAyurveda, an ancient holistic healing system originating from India emphasizes balance and harmony between body, mind, and spirit. Ayurvedic medicines offer diverse therapeutic claims, spanning preventive care, disease treatment, and overall well-being ...
Suvarna Ingale +2 more
doaj
Differences in spatial memory recognition due to cognitive style [PDF]
, 2017 Field independence refers to the ability to perceive details from the surrounding context as a whole and to represent the environment by relying on an internal reference frame.
Boccia, Maddalena +3 more
core +3 more sources
FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
Exploring the mechanism of action of rehmannia glutinosa for the treatment of gastric cancer based on network pharmacology [PDF]
Brazilian Journal of Pharmaceutical SciencesThis study investigates the molecular mechanisms of Rehmannia glutinosa in gastric cancer treatment using network pharmacology, supported by experimental validation.
Han Yongguang +4 more
doaj +1 more source
Synthesis and Biological Characterization of a New Norbormide Derived Bodipy FL-Conjugated Fluorescent Probe for Cell Imaging [PDF]
, 2018 Background: Norbormide (NRB) is a selective rat toxicant endowed with vasoconstrictor activity confined to the rat peripheral arteries. In a recent work we used a fluorescent derivative of NRB (NRB-AF12), obtained by coupling the NBD fluorophore to the ...
Bova, Sergio +9 more
core +3 more sources