Results 101 to 110 of about 628,285 (376)
On the Randić index and its variants of network data [PDF]
TEST 2023, 2023 Summary statistics play an important role in network data analysis. They can provide us with meaningful insight into the structure of a network. The Randi\'{c} index is one of the most popular network statistics that has been widely used for quantifying information of biological networks, chemical networks, pharmacologic networks, etc.
arxiv
Network Pharmacology Analysis of the Potential Pharmacological Mechanism of a Sleep Cocktail
BiomoleculesInsomnia, also known as sleeplessness, is a sleep disorder due to which people have trouble sleeping, followed by daytime sleepiness, low energy, irritability, and a depressed mood. It may result in an increased risk of accidents of all kinds as well as problems focusing and learning.
Yuyun Liang +3 more
openaire +3 more sources
FEBS Open Bio, Volume 15, Issue 5, Page 836-855, May 2025.Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy +14 more
wiley +1 more source
Frontiers in Pharmacology, 2014 The development of clinical practice recommendations or guidelines for the clinical use of pharmacogenomics data is an essential issue for improving drug therapy, particularly for drugs with high toxicity and/or narrow therapeutic index such as ...
José A G Agúndez +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
Network pharmacology approach for validation of traditional claims of Ayurvedic medicines [PDF]
Network BiologyAyurveda, an ancient holistic healing system originating from India emphasizes balance and harmony between body, mind, and spirit. Ayurvedic medicines offer diverse therapeutic claims, spanning preventive care, disease treatment, and overall well-being ...
Suvarna Ingale +2 more
doaj
PhIN: A Protein Pharmacology Interaction Network Database [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2015 Network pharmacology is a new and hot concept in drug discovery for its ability to investigate the complexity of polypharmacology, and becomes more and more important in drug development. Here we report a protein pharmacology interaction network database (PhIN), aiming to assist multitarget drug discovery by providing comprehensive and flexible network
L Liang +4 more
openaire +3 more sources
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
World Journal of Traditional Chinese Medicine, 2018 Objective: To investigate the network pharmacology of Shexiang Baoxin pill (SBP) and systematically analyze the mechanisms of SBP. Methods: In this study, we excavated all the targets of 26 constituents of SBP which were identified in rat plasma though ...
Shou-De Zhang +7 more
doaj +1 more source
Predicting new molecular targets for rhein using network pharmacology [PDF]
, 2012 Background Drugs can influence the whole biological system by targeting interaction reactions. The existence of interactions between drugs and network reactions suggests a potential way to discover targets.
Sun, Hui +3 more
core +3 more sources