Results 121 to 130 of about 7,014,814 (396)

Network pharmacology approach for validation of traditional claims of Ayurvedic medicines [PDF]

Network Biology
Ayurveda, an ancient holistic healing system originating from India emphasizes balance and harmony between body, mind, and spirit. Ayurvedic medicines offer diverse therapeutic claims, spanning preventive care, disease treatment, and overall well-being ...
Suvarna Ingale, Tejal Bele, Pramod Ingale   +2 more
doaj  

Computer-aided drug design to generate a unique antibiotic family

Nature Communications
The World Health Organization has identified antibiotic resistance as one of the three greatest threats to human health. The need for antibiotics is a pressing matter that requires immediate attention.
Christopher J. Barden, Fan Wu, J. Pedro Fernandez-Murray, Erhu Lu, Shengguo Sun, Marcia M. Taylor, Annette L. Rushton, Jason Williams, Mahtab Tavasoli, Autumn Meek, Alla Siva Reddy, Lisa M. Doyle, Irina Sagamanova, Kovilpitchai Sivamuthuraman, Robert T. M. Boudreau, David M. Byers, Donald F. Weaver, Christopher R. McMaster   +17 more
doaj   +1 more source

Effects of Pharmacologic and Nonpharmacologic Interventions for the Management of Sleep Problems in People With Fibromyalgia: Systematic Review and Network Meta‐Analysis of Randomized Controlled Trials

Arthritis Care &Research, EarlyView.
Objective Fibromyalgia is a chronic condition characterized by widespread musculoskeletal pain and fatigue. Almost everyone with fibromyalgia has sleep problems. We aimed to evaluate the effectiveness and safety of current interventions for the management of fibromyalgia‐related sleep problems.
Jemma Hudson, Mari Imamura, Clare Robertson, Daniel Whibley, Lorna Aucott, Katie Gillies, Paul Manson, Debra Dulake, Abhishek Abhishek, Nicole K. Y. Tang, Gary J. Macfarlane, Miriam Brazzelli   +11 more
wiley   +1 more source

Peer Review Certifies Quality and Innovation in Clinical Pharmacology & Therapeutics. [PDF]

, 2017
Clinical Pharmacology & Therapeutics (CPT) is an established voice of the discipline, a trusted source of new knowledge showcasing discovery, translation, and application of novel therapeutic paradigms to advance the management of patients and ...
Terzic, Andre M., Waldman, Scott A.
core   +2 more sources

Exploring the pathways and targets of Shexiang Baoxin pill for coronary heart disease through a network pharmacology approach

World Journal of Traditional Chinese Medicine, 2018
Objective: To investigate the network pharmacology of Shexiang Baoxin pill (SBP) and systematically analyze the mechanisms of SBP. Methods: In this study, we excavated all the targets of 26 constituents of SBP which were identified in rat plasma though ...
Shou-De Zhang, Zhan-Hai Su, Rui-Hui Liu, Yan-Yan Diao, Shi-Liang Li, Ya-Ping-Hua, Hong-Lin Li, Wei-Dong Zhang   +7 more
doaj   +1 more source

Longitudinal Relationship Between Pain and Depression in People With Inflammatory Arthritis: A Narrative Review

Arthritis Care &Research, EarlyView.
As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox, Saeed Farooq, Helen Twohig, Ian C. Scott   +3 more
wiley   +1 more source

Lived and care experiences of chronic musculoskeletal shoulder pain in Australian adults: A qualitative study

Arthritis Care &Research, Accepted Article.
Objectives Australian evidence on lived and care experiences of chronic musculoskeletal shoulder pain (CMSP), irrespective of disorder classification or disease, is limited. However, such evidence is important for person‐centred care and informing local service pathways and care guidelines or standards.
Sonia Ranelli, Joanne E. Jordan, Ilana N. Ackerman, Alison Thorpe, Jennifer G. Persaud, Linda J. Woodhouse, Jason Chua, Ben Horgan, Andrew M. Briggs   +8 more
wiley   +1 more source

Reading a story. Different degrees of learning in different learning environments [PDF]

, 2017
he learning environment in which material is acquired may produce differences in delayed recall and in the elements that individuals focus on. These differences may appear even during development.
Cordellieri, Pierluigi, Giannini, Anna Maria, Piccardi, Laura   +2 more
core   +1 more source

Forskolin Enhances Urokinase Plasminogen Activator Secretion and Angiogenic Activity of Xeno‐Free Cultures of Human Adipose Tissue‐Derived Stem Cells

Advanced Biology, EarlyView.
The regenerative potential of adipose tissue‐derived stem cells can be enhanced through chemical stimulation in vitro. A short stimulation protocol using forskolin, either alone or in combination with other growth factors, under xeno‐free conditions enhanced the pro‐angiogenic responses in human ASCs.
Maria Vittoria Giraudo, Anne Therese Lauvrud, Rebecca Wiberg, Maria Brohlin, Gustav Andersson, Paul J Kingham   +5 more
wiley   +1 more source

Network pharmacology for mechanistically redefined comorbidities [PDF]

, 2020
Diabetes, hypertension and stroke are common comorbidities and the leading causes of death. Current therapies are symptom-oriented and are imprecise. One main reason for this is that these complex diseases are defined by a symptom in an organ and not by a molecular mechanism. Network medicine, however, shows that within the diseasome these comorbidites
openaire   +3 more sources