Results 51 to 60 of about 628,285 (376)

Molecular networks for the study of TCM Pharmacology [PDF]

Briefings in Bioinformatics, 2009
To target complex, multi-factorial diseases more effectively, there has been an emerging trend of multi-target drug development based on network biology, as well as an increasing interest in traditional Chinese medicine (TCM) that applies a more holistic treatment to diseases.
Peng Jiang, Wei-Dong Zhang, Jing Zhao
openaire   +3 more sources

Machine-learning Analysis of Opioid Use Disorder Informed by MOR, DOR, KOR, NOR and ZOR-Based Interactome Networks [PDF]

arXiv, 2023
Opioid use disorder (OUD) continuously poses major public health challenges and social implications worldwide with dramatic rise of opioid dependence leading to potential abuse. Despite that a few pharmacological agents have been approved for OUD treatment, the efficacy of said agents for OUD requires further improvement in order to provide safer and ...
arxiv  

Combining metabolomics and network pharmacology to investigate the protective effect of Jiawei Xinglou Chengqi Granules in ischemic stroke [PDF]

Brazilian Journal of Medical and Biological Research
Jiawei Xinglou Chengqi Granule (JXCG) is an effective herbal medicine for the treatment of ischemic stroke (IS). JXCG has been shown to effectively ameliorate cerebral ischemic symptoms in clinical practice, but the underlying mechanisms are unclear.
Raoqiong Wang, Linshen Mao, Pan Liang, Yulu Gan, Qixue Gao, Shizhi Liang, Dechou Zhang, Gang Luo, Sijin Yang   +8 more
doaj   +1 more source

Integrative transcriptomic and network pharmacology analysis reveals the neuroprotective role of BYHWD through enhancing autophagy by inhibiting Ctsb in intracerebral hemorrhage mice

Chinese Medicine, 2023
Background In this study, we aimed to combine transcriptomic and network pharmacology to explore the crucial mRNAs and specific regulatory molecules of Buyang Huanwu Decoction (BYHWD) in intracerebral hemorrhage (ICH) treatment. Methods C57BL/6 mice were
Yiqing Cai, Zhe Yu, Xueping Yang, Weikang Luo, En Hu, Teng Li, Wenxin Zhu, Yang Wang, Tao Tang, Jiekun Luo   +9 more
doaj   +1 more source

Network Pharmacology Approach for Medicinal Plants: Review and Assessment

Pharmaceuticals, 2022
Natural products have played a critical role in medicine due to their ability to bind and modulate cellular targets involved in disease. Medicinal plants hold a variety of bioactive scaffolds for the treatment of multiple disorders.
Fatima Noor, Muhammad Tahir ul Qamar, Usman Ali Ashfaq, Aqel Albutti, Ameen S. S. Alwashmi, Mohammad Abdullah Aljasir   +5 more
doaj   +1 more source

Communities of attention networks: introducing qualitative and conversational perspectives for altmetrics [PDF]

Scientometrics, 2020, 2020
We propose to analyze the level of recommendation and spreading in the sharing of scientific papers on Twitter to understand the interactions of communities around papers and to develop the "Community of Attention Network" (CAN). In this paper, a pilot case study was conducted for the paper 'Pharmacological Treatment of Obesity' authored by Mancini ...
arxiv   +1 more source

Systems Pharmacology [PDF]

, 2008
The slides are from a presentation given by Professor Ravi Iyengar from Mount Sinai School of Medicine at the Drug Forum Meeting #9 that took place in Washington, DC on February 20-21, 2008.
Ravi Iyengar
core   +2 more sources

Andrographolide in atherosclerosis: integrating network pharmacology and in vitro pharmacological evaluation

Bioscience Reports, 2022
Abstract Objective: Andrographis paniculata (Burm.f.) Nees is a medicinal plant that has been traditionally used as an anti-inflammatory and antibacterial remedy for several conditions. Andrographolide (AG), the active constituent of A. paniculata (Burm.f.) Nees, has anti-lipidic and anti-inflammatory properties as well as cardiovascular
Shuai Shi, Xinyu Ji, Jingjing Shi, Shuqing Shi, Fei She, Qiuyan Zhang, Yu Dong, Hanming Cui, Yuanhui Hu   +8 more
openaire   +2 more sources

Analyzing the research landscape: Mapping frontiers and hot spots in anti-cancer research using bibliometric analysis and research network pharmacology

Frontiers in Pharmacology, 2023
Introduction: Network pharmacology has emerged as a forefront and hotspot in anti-cancer. Traditional anti-cancer drugs are limited by the paradigm of “one cancer, one target, one drug,” making it difficult to address the challenges of recurrence and ...
Qi Han, Qi Han, Zhongxun Li, Zhongxun Li, Yang Fu, Hongliang Liu, Hongliang Liu, Hongliang Liu, Hongliang Liu, Huina Guo, Huina Guo, Xiaoya Guan, Xiaoya Guan, Min Niu, Min Niu, Chunming Zhang, Chunming Zhang, Chunming Zhang   +17 more
doaj   +1 more source

Network Pharmacology, Molecular Docking, and MR Analysis: Targets and Mechanisms of Gegen Qinlian Decoction for Helicobacter pylori [PDF]

arXiv, 2023
Objective: The study explored therapeutic targets and mechanisms of Gegen Qinlian Decoction for Helicobacter pylori infection and related gastric cancer using network pharmacology, molecular docking, and Mendelian randomization. Methods: Medicinal components of Gegen Qinlian Decoction were extracted from TCMSP and HERB databases.
arxiv