Results 51 to 60 of about 7,014,814 (396)

Network Pharmacology

, 2017
The one-drug/one-target/one-disease approach to drug discovery is presently facing many challenges of safety, efficacy, and sustainability. Network biology and polypharmacology approaches gained appreciation recently as methods for omics data integration and multitarget drug development, respectively.
Saniya Patil, Rathnam Chaguturu, Neelay Mehendale, Bhushan Patwardhan, Uma Chandran   +4 more
openaire   +2 more sources

Network Pharmacology Prediction and Molecular Docking-Based Strategy to Discover the Potential Pharmacological Mechanism of Huai Hua San Against Ulcerative Colitis

Drug Design, Development and Therapy, 2021
Background Huai Hua San (HHS), a famous Traditional Chinese Medicine (TCM) formula, has been widely applied in treating ulcerative colitis (UC). However, the interaction of bioactives from HHS with the targets involved in UC has not been elucidated yet ...
Jiaqin Liu, Jian Liu, Xiaoliang Tong, Weijun Peng, Shan-shan Wei, Taoli Sun, Yikun Wang, Bi-kui Zhang, Wenqun Li   +8 more
semanticscholar   +1 more source

Molecular networks for the study of TCM Pharmacology [PDF]

Briefings in Bioinformatics, 2009
To target complex, multi-factorial diseases more effectively, there has been an emerging trend of multi-target drug development based on network biology, as well as an increasing interest in traditional Chinese medicine (TCM) that applies a more holistic treatment to diseases.
Peng Jiang, Wei-Dong Zhang, Jing Zhao
openaire   +3 more sources

Combining metabolomics and network pharmacology to investigate the protective effect of Jiawei Xinglou Chengqi Granules in ischemic stroke [PDF]

Brazilian Journal of Medical and Biological Research
Jiawei Xinglou Chengqi Granule (JXCG) is an effective herbal medicine for the treatment of ischemic stroke (IS). JXCG has been shown to effectively ameliorate cerebral ischemic symptoms in clinical practice, but the underlying mechanisms are unclear.
Raoqiong Wang, Linshen Mao, Pan Liang, Yulu Gan, Qixue Gao, Shizhi Liang, Dechou Zhang, Gang Luo, Sijin Yang   +8 more
doaj   +1 more source

Curcumin and its nano-formulations: Defining triple-negative breast cancer targets through network pharmacology, molecular docking, and experimental verification

Frontiers in Pharmacology, 2022
Background: Curcumin (CUR) displays the capability of suppressing the proliferation and metastasis of various cancer cells. However, the effects and underline mechanisms of CUR to treat triple-negative breast cancer (TNBC) have not been systematically ...
Zhicheng Deng, Guanghui Chen, Yonghui Shi, Ying Lin, Jiebin Ou, Hua Zhu, Junyan Wu, Guocheng Li, Li Lv   +8 more
semanticscholar   +1 more source

Clinical Pharmacology & Therapeutics: Past, Present, and Future. [PDF]

, 2017
Clinical Pharmacology & Therapeutics (CPT), the definitive and timely source for advances in human therapeutics, transcends the drug discovery, development, regulation, and utilization continuum to catalyze, evolve, and disseminate discipline ...
Terzic, Andre, Waldman, Scott A.
core   +2 more sources

Research into the mechanism of intervention of SanQi in endometriosis based on network pharmacology and molecular docking technology

Medicine, 2022
Background: By using network pharmacology and molecular docking technology, we have explored the mechanism of action of Sanqi in the treatment of endometriosis (EMS), in order to provide reference for clinical studies of Chinese medicine treatment of Ems
Zhiheng Lin, weisen fan, Xiao Yu, Jinxing Liu, P. Liu   +4 more
semanticscholar   +1 more source

Integrative transcriptomic and network pharmacology analysis reveals the neuroprotective role of BYHWD through enhancing autophagy by inhibiting Ctsb in intracerebral hemorrhage mice

Chinese Medicine, 2023
Background In this study, we aimed to combine transcriptomic and network pharmacology to explore the crucial mRNAs and specific regulatory molecules of Buyang Huanwu Decoction (BYHWD) in intracerebral hemorrhage (ICH) treatment. Methods C57BL/6 mice were
Yiqing Cai, Zhe Yu, Xueping Yang, Weikang Luo, En Hu, Teng Li, Wenxin Zhu, Yang Wang, Tao Tang, Jiekun Luo   +9 more
doaj   +1 more source

Network pharmacology combined with experimental verification to explore the potential mechanism of naringenin in the treatment of cervical cancer

Scientific Reports
Cervical cancer is the second leading cause of morbidity and mortality in women worldwide. Traditional treatment methods have become limited. Naringenin, a flavonoid abundant in various fruits and herbal medicines, has demonstrated anti-tumor properties ...
Ji Zhou, Haoying Li, Ben Wu, Lemei Zhu, Qiao Huang, Zhenyu Guo, Qizhi He, Lin Wang, Xiaozhen Peng, Tianyao Guo   +9 more
semanticscholar   +1 more source

Network Pharmacology-Based Strategy to Investigate the Pharmacologic Mechanisms of Coptidis Rhizoma for the Treatment of Alzheimer's Disease

Frontiers in Aging Neuroscience, 2022
Background Alzheimer's disease (AD) is becoming a more prevalent public health issue in today's culture. The experimental study of Coptidis Rhizoma (CR) and its chemical components in AD treatment has been widely reported, but the principle of multi ...
Xian-wen Ye, Hai-li Wang, Shui-qing Cheng, Liangfang Xia, Xinxin Xu, Xiang-ri Li   +5 more
semanticscholar   +1 more source