Results 71 to 80 of about 7,014,814 (396)
Network pharmacology: a crucial approach in traditional Chinese medicine research
Chinese MedicineNetwork pharmacology plays a pivotal role in systems biology, bridging the gap between traditional Chinese medicine (TCM) theory and contemporary pharmacological research.
Yiyan Zhai +12 more
doaj +1 more source
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Network Pharmacology of Adaptogens in the Assessment of Their Pleiotropic Therapeutic Activity
Pharmaceuticals, 2022 The reductionist concept, based on the ligand–receptor interaction, is not a suitable model for adaptogens, and herbal preparations affect multiple physiological functions, revealing polyvalent pharmacological activities, and are traditionally used in ...
A. Panossian, T. Efferth
semanticscholar +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Contrast Media & Molecular Imaging, 2022 Background. As a classic prescription in Chinese medicine treatment, Xiaochaihutang (XCHT) can improve the clinical effect and reduce serum tumor markers in patients with breast cancer (BC). However, there has not been any study to confirm the mechanism. We used bioinformatics analysis and network pharmacology to find the potential targets.
Lin Zheng +5 more
openaire +2 more sources
How Can Network-Pharmacology Contribute to Antiepileptic Drug Development? [PDF]
, 2014 Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant magic bullet paradigm which proposed the search of exquisitely selective drugs. What is
Di Ianni, Mauricio Emiliano +1 more
core +1 more source
Quantifying the Diaspora of Knowledge in the Last Century [PDF]
, 2016 Academic research is driven by several factors causing different disciplines to act as "sources" or "sinks" of knowledge. However, how the flow of authors' research interests -- a proxy of human knowledge -- evolved across time is still poorly understood.
Arenas, Alex +2 more
core +2 more sources
Chinese Medicine, 2022 Background Xian-ling-lian-xia-fang (XLLXF), a Chinese medicine decoction, is widely used in the treatment of triple negative breast cancer (TNBC). However, the underlying mechanism of XLLXF in TNBC treatment has not been totally elucidated. Methods Here,
Feifei Li +10 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Background: In this research, we aimed to explore the efficacy of diallyl trisulfide (DATS) combined with cisplatin (DDP) for gastric cancer treatment and its underlying mechanism based on network pharmacology.Methods: First, the pharmacological ...
Huaiyou Lv +9 more
doaj +1 more source
Plants, 2022 Metabolomic is generally characterized as a comprehensive and the most copious analytical technique for the identification of targeted and untargeted metabolite diversity in a biological system.
B. Sharma, Dinesh Yadav
semanticscholar +1 more source