Results 91 to 100 of about 574,210 (309)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Line structure representation for multi-level pedestrian network analysis

open access: yes, 2018
This paper introduces the line structure of road network as a mean of representing pedestrian network in Hong Kong. In Hong Kong the pedestrian network combines both steep topographies as for the road network and separation from the road network due to ...
Chiaradia, A.J.F.   +3 more
core  

The Optimization Model of Runway and Gate Assignment

open access: yesCivil Engineering Dimension, 2013
This paper is aimed to develop the optimization model of time slot utilization for both runway and apron gate of airport system. The model considers the objectives of airline company to minimize flight-taxiing-time and waiting-time for both landing and ...
Nahry ., Tjahjono T., Satiti Y.J.
doaj  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

A nationwide study of the epidemiology of relapsing polychondritis

open access: yesClinical Epidemiology, 2016
Anna Horváth,1 Nóra Páll,2 Katalin Molnár,1 Tamás Kováts,3 György Surján,3 Tamás Vicsek,4,5 Péter Pollner2,4 13rd Department of Internal Medicine, Semmelweis University, 2Regional ...
Horváth A   +6 more
doaj  

Multi-channel high-order network representation learning research

open access: yesFrontiers in Neurorobotics
The existing network representation learning algorithms mainly model the relationship between network nodes based on the structural features of the network, or use text features, hierarchical features and other external attributes to realize the network ...
Zhonglin Ye   +4 more
doaj   +1 more source

Representations of the Multicast Network Problem [PDF]

open access: yes, 2017
We approach the problem of linear network coding for multicast networks from different perspectives. We introduce the notion of the coding points of a network, which are edges of the network where messages combine and coding occurs. We give an integer linear program that leads to choices of paths through the network that minimize the number of coding ...
Anderson, Sarah E.   +6 more
openaire   +3 more sources

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