Results 121 to 130 of about 7,091,614 (353)
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
Dizhen xuebao鲁东—黄海地块西部为华北地块东侧的次级地块，其地震活动具有显著的周期特征，地块内部的中强地震活动特征和周边大震对该地区的影响对研究该地区地震活动状态有重要意义。采用小波分析方法定量计算了鲁东—黄海地块西部历史地震的活动周期，并结合中强地震活动的定性分析、时空演化、能量释放及周边大震等资料，探讨了该地区的地震活动特征。结果显示：① 鲁东—黄海地块西部M5.0以上地震活动存在着60.6—78.6 a的长周期，该周期反映了地震活跃—平静的韵律特征，据此M≥5.0地震可划分为活跃时段 Ⅰ （1844—1879年）
Mingxiao Li +6 more
doaj +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Routing and broadcasting over sensor networks [PDF]
, 2008 textAdvances in micro-embedded computing systems, coupled with developments in wireless technology have enabled the deployment of large scale wireless and sensor networks for many important applications.
Subramanian, Sundar, 1981-
core
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
地震科学进展In this paper, the regional full waveform inversion using the broadband waveforms recorded by China Seismic Network were conducted, and the focal mechanism solutions of the 62 earthquakes with M≥4.0 occurred in the mainland of China during November 2023 ...
Shanshan Liang +3 more
doaj +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
IEEE Open Journal of the Communications Society6G millimeter-wave (mmWave) networks are expected to provide widespread multi-Gbit/s connectivity. However, increased sensitivity to obstacle blockage leads to underconnected shadow regions, motivating the introduction of intelligent reflecting surfaces (
Simon Hager +4 more
doaj +1 more source