Results 121 to 130 of about 2,970,315 (253)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Determination of focal mechanism solutions of the earthquakes with M≥4.0 occurred in the mainland of China during November 2023 to February 2024

地震科学进展
In this paper, the regional full waveform inversion using the broadband waveforms recorded by China Seismic Network were conducted, and the focal mechanism solutions of the 62 earthquakes with M≥4.0 occurred in the mainland of China during November 2023 ...
Shanshan Liang, Liye Zou, Yanqiong Liu, Xiao Ren   +3 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Field Performance Evaluation of a Mechatronic Reflector System in a Private mmWave Network Environment

IEEE Open Journal of the Communications Society
6G millimeter-wave (mmWave) networks are expected to provide widespread multi-Gbit/s connectivity. However, increased sensitivity to obstacle blockage leads to underconnected shadow regions, motivating the introduction of intelligent reflecting surfaces (
Simon Hager, Marcel Kaudewitz, Florian Schmickmann, Stefan Bocker, Christian Wietfeld   +4 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Taming the reservoir : feedforward training for recurrent neural networks

, 2012
Recurrent neural networks are successfully used for tasks like time series processing and system identification. Many of the approaches to train these networks, however, are often regarded as too slow, too complicated, or both.
Obst, Oliver, Obst, Oliver (R18459), Martin Riedmiller, Riedmiller, Martin, Oliver Obst   +4 more
core   +1 more source

Impact of Public Protests on Mobile Networks [PDF]

The roll out of 5G, coupled with the traffic monitoring capabilities of modern industry-grade networks, offers an unprecedented opportunity to closely observe the impact that the introduction of a new major wireless technology has on the end users.
Martínez-Durive, Orlando E., Fiore, Marco, Zanella, André, Mishra, Sachit, Madariaga, Diego   +4 more
core   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source