Results 71 to 80 of about 6,797,677 (284)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Dizhen xuebao, 2019 预测效果的科学评价是预测学科必须要解决的问题，对地震预测效果的评价一般分为两种，一种是对单次预测成败的评判，另一种是对方法或手段多次预测效果的统计评分。本文提出了针对单次有震预测是否准确的定量评价方法，即地震预测准确性A值评分法。针对我国地震预测现状，本文约定了准确性评分由预测与实际地震的对应情况（简称“对应度” ）和时、空、强预测窗口的精确程度（简称“精确度” ）综合决定，同时，还给出了对应度的计算方法和精确度的评价标准。通过对四川省地震局2013年2月上报的短期预测意见进行试算 ...
Wei Yan +6 more
doaj +1 more source
Cancer gene expression profiles associated with clinical outcomes to chemotherapy treatments
BMC Medical Genomics, 2020 Background Machine learning (ML) methods still have limited applicability in personalized oncology due to low numbers of available clinically annotated molecular profiles.
Nicolas Borisov +4 more
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Real Options and the Costs of the Local Telecommunications Network [PDF]
The Telecommunications Act of 1996 invites entry in the local telecommunications networks whereby entrants will lease parts of the network ("unbundled network elements") from incumbents "at cost plus reasonable profit." A crucial question in the ...
Nicholas Economides
core
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Rapid 3D printing of hierarchical nanoporous copper structures with self-disintegration capability
Nature CommunicationsMicro-architected nanoporous metals are widely used in electrochemical and catalytic systems, but conventional powder metallurgy cannot readily produce structurally complex, microscale variants.
Luyang Liu +10 more
doaj +1 more source
A Critical Appraisal of Remedies in the EU Microsoft Cases [PDF]
We discuss and compare the remedies in the two cases antitrust cases of the European Union (EU) against Microsoft. The first EU case alleged (i) that Microsoft illegally bundled the Windows Media Player (WMP) with Windows; and (ii) that Microsoft did not
Ioannis Lianos, Nicholas Economides
core
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
地震科学进展In this paper，the regional full waveform inversion using the broadband waveforms recorded by China Seismic Network were conducted，and the focal mechanism solutions of the 59 earthquakes with M≥4.0 occurred in the mainland of China during March to June ...
Shanshan Liang +4 more
doaj +1 more source