Results 131 to 140 of about 1,943 (161)

Synthesis and Biological Evaluation of Several Dephosphonated Analogues of CMP‐Neu5Ac as Inhibitors of GM3‐Synthase

Chemistry – A European Journal, 2015
AbstractPrevious studies demonstrated that reducing the GM3 content in myoblasts increased the cell resistance to hypoxic stress, suggesting that a pharmacological inhibition of the GM3 synthesis could be instrumental for the development of new treatments for ischemic diseases.
P. Rota, F. Cirillo, M. Piccoli, A. Gregorio, G. Tettamanti, P. Allevi, L. Anastasia   +6 more
openaire   +2 more sources

Purification and partial characterization of CMP-Neu5Ac synthetase from rat brain

Analytica Chimica Acta, 2006
Abstract N -Acetyl-neuraminic acid cytidylyltransferase (EC 2.7.7.43) (CMP-Neu5Ac synthetase), which catalyzes the formation of cytidine-5′-monophospho- N -acetyl-neuraminic acid (CMP-Neu5Ac) from cytidine-5′-triphosphate (CTP) and N -acetyl-neuraminic acid (Neu5Ac), was purified from rat brains aged 8–9 days, which presented the highest specific ...
J.C. Feo-Manga, L.B. Rodríguez-Aparicio, M.A. Ferrero, A. Reglero   +3 more
openaire   +1 more source

ChemInform Abstract: Synthesis of Phosphonic Acid Analogues of Sialic Acid Neu5Ac.

ChemInform, 1996
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
T.‐H. CHAN, Y.‐C. XIN
openaire   +1 more source

Structural Basis for Binding of Fluorescent CMP-Neu5Ac Mimetics to Enzymes of the Human ST8Sia Family

ACS Chemical Biology, 2018
Polysialyltransferases synthesize polysialic acid on cell surface-expressed glycoconjugates, which is crucial for developing processes and signaling pathways in eukaryotes. Recent advances in cancer research have rendered polysialyltransferases important drug targets because polysialic acid contributes to cancer cell progression, metastasis, and ...
Gesa Volkers, Christian Lizak, Jürgen Niesser, Frederico I. Rosell, Johannes Preidl, Vinayaga S. Gnanapragassam, Ruediger Horstkorte, Jörg Rademann, Natalie C. J. Strynadka   +8 more
openaire   +2 more sources

[Synthesis of Neu5Ac(alpha2-->6)[Gal(alpha1-->3)]GalNAcalpha and Neu5Ac(alpha2-->6)[Gal(beta1-->3)]GalNAcalpha trisaccharides as protected trifluoroacetamidopropyl glycosides].

Bioorganicheskaia khimiia, 1999
Protected sialo-containing trisaccharides, fragments of oligosaccharide chains of mucin glycoproteins, were synthesized. Regioselective sialylation of the primary hydroxyl group of (3-fluoroacetamidopropyl)-2-azido-2-deoxy-3-O-(2,3,4,6-tetra-O-ben zyl)-alpha -D-galactopyranosyl)-alpha-D-galactopyranoside with methyl ester of peracetyl-beta ...
L A, Simeoni, N E, Baĭramova, N V, Bovin   +2 more
openaire   +1 more source

Enzymatic method for preparation of CMP-Neu5Ac

2021
REXER THOMAS F T, MAHOUR REZA
openaire   +4 more sources

Synthesis of phosphonic acid analogues of sialic acid Neu5Ac

Chemical Communications, 1996
Tak-Hang Chan, Yan-Chao Xin
openaire   +1 more source

Neu5Acα2,6Gal and Neu5Acα2,3Gal receptor specificities on influenza viruses determined by a waveguide-mode sensor

Acta Biomaterialia, 2013
Koichi Awazu, Xiaomin Wang, Gopinath Subash   +2 more
exaly  

Synthesis of Neu5Ac Oligosaccharides and Analogues by Transglycosylation and their Binding Properties as Ligands to MAG

ChemBioChem, 2006
Björn, Neubacher, Svenja, Scheid, Sørge, Kelm, Alberto C, Frasch, Bernd, Meyer, Joachim, Thiem   +5 more
openaire   +2 more sources

Expression of Neu5Acα2,3Gal and Neu5Acα2,6Gal on the nasal mucosa of patients with chronic rhinosinusitis and its possible effect on bacterial biofilm formation

Microbial Pathogenesis, 2018
Qinying Wang, Haihong Chen
exaly