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Synthesis of α- and β-Methyl NEU5Ac α-(2→8) NEU5Ac Disaccharides
Journal of Carbohydrate Chemistry, 1990ABSTRACT Acid hydrolysis of colominic acid, an α-(2→8)-linked oligomer of sialic acid, yielded Neu5Ac α-(2→8) Neu5Ac (di-Neu5Ac) 2 as one of the products. Starting from this disaccharide, it was possible to prepare two potential di-Neu5Ac donors, 5 and 8, as their corresponding 2-chloro derivatives. Subsequent reaction of the donor 8 with methanol as a
S.Z. Abbas +4 more
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Synthesis of Neu5Ac, KDN, and KDO C-Glycosides
ChemInform, 2005AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access the actual ChemInform Abstract, please click on HTML or PDF.
Chi‐Chang Chen +2 more
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Stereoselective Total Syntheses of (+)-Castanospermine and Neu5Ac Methyl Ester
The Journal of Organic Chemistry, 2019Concise and stereocontrolled total syntheses of (+)-castanospermine and N-acetylneuraminic acid methyl ester were achieved from diastereomerically enriched anti, syn, syn-1,3-oxazine and anti, syn, anti-1,3-oxazine, respectively. The key step in this strategy was the stereoselective BF3·OEt2-mediated allylation.
In-Soo Myeong +3 more
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Organic Letters, 2000
Sialic acid and its analogues have been synthesized using a salenCo(II) complex catalyzed hetero Diels-Alder reaction and oxidative azidation (CAN/NaN3) of silyl enol ether as the key steps.
, Li, , Wu, , Wu
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Sialic acid and its analogues have been synthesized using a salenCo(II) complex catalyzed hetero Diels-Alder reaction and oxidative azidation (CAN/NaN3) of silyl enol ether as the key steps.
, Li, , Wu, , Wu
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ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Lian‐Sheng Li, Yu‐Lin Wu, Yikang Wu
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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Lian‐Sheng Li, Yu‐Lin Wu, Yikang Wu
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A New Synthesis of Neu5Ac from
A new route to Neu5Ac methyl ester (23) with a readily available sugar D-glucono-delta-lactone as starting material has been developed. A diastereoselective propargylation of alpha-acetamino aldehyde and a subsequent KMnO(4) oxidation of the terminal alkyne served as the key steps.
Ke-Gang, Liu +3 more
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An investigation into Neu5Ac aldolase and KDN-cleaving sialidase
2021The author retains copyright of this thesis. It must only be used for personal non-commercial research, education and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission. For further terms on this licence: https://rightsstatements.org/page/InC-EDU/1.0/?language=en Contact ...
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A convenient synthesis of nucleoside monophosphate-N-acetylneuraminic acids (NMP-Neu5AC)
Bioorganic & Medicinal Chemistry, 1994Reaction of sialyl phosphites 2a,b with acetyl-protected ribonucleoside monophosphates 3C, 3U, 3A and 3G furnished without addition of a catalyst directly the corresponding beta-configurated sialyl ribonucleoside monophosphates 4C, 4U, 4A and 4G, respectively.
T J, Martin, H, Braun, R R, Schmidt
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Model-based Optimization of Neu5Ac Synthesis
2023Sialic acids (SAs) are a group of more than 50 structurally distinct α-keto acids found in viruses, mammalian cells, and microorganisms1. They control various biological functions such as development, recognition, cell signaling, cell-cell interactions, and adhesion2. Sialylation of neural cell adhesion molecules during embryonic development is crucial
Çakar, Mehmet Mervan +1 more
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The synthesis of sialylated oligosaccharides using a CMP-Neu5Ac synthetase/sialyltransferase fusion
Nature Biotechnology, 1998Large-scale enzymatic synthesis of oligosaccharides, which contain terminal N-acetyl-neuraminic acid residues requires large amounts of the sialyltransferase and the corresponding sugar-nucleotide synthetase, which is required for the synthesis of the sugar-nucleotide donor, CMP-Neu5Ac.
M, Gilbert +7 more
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