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Neurospheres: Insights into neural stem cell biology

Journal of Neuroscience Research, 2004
AbstractNeural stem cells (NSC) are a tissue‐specific subtype of self‐renewing and multipotent cells that can give rise to all neural populations. In this review, the importance of maintaining cell–cell contacts in the study of NSC is highlighted, and data obtained from some crucial single‐cell studies is compared to results obtained from neurospheres,
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Enteric neural crest‐derived cells and neural stem cells: biology and therapeutic potential

Neurogastroenterology & Motility, 2004
AbstractThe enteric nervous system arises from two regions of the neural crest; the vagal neural crest which gives rise to the vast majority of enteric neurones throughout the gastrointestinal tract, and the sacral neural crest which contributes a smaller number of cells that are mainly distributed within the hindgut.
A J, Burns, P J, Pasricha, H M, Young
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Neural crest cells: From developmental biology to clinical interventions

Birth Defects Research Part C: Embryo Today: Reviews, 2014
Neural crest cells are multipotent cells, which are specified in embryonic ectoderm in the border of neural plate and epiderm during early development by interconnection of extrinsic stimuli and intrinsic factors. Neural crest cells are capable of differentiating into various somatic cell types, including melanocytes, craniofacial cartilage and bone ...
Parinya, Noisa, Taneli, Raivio
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Biology and Clinical Application of Neural Stem Cells

Hormone Research in Paediatrics, 2003
Neural stem cells, which exist in various regions of the CNS throughout the mammalian lifespan, can be expanded and induced to differentiate into neurons and glia in vitro and in vivo. Because of these characteristics, there has been increasing interest in the identification and characterization of neural stem cells and neural progenitor cells both for
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Stem cell neural differentiation: a model for chemical biology

Current Opinion in Chemical Biology, 2006
Stem cells can produce progenies that constitute an organism or a tissue while replenishing (renewing) themselves. The ability to produce large quantities of stage-specific cells from self-renewing stem cells in a precisely controlled manner makes it possible to dissect out complex interactions among macromolecules along development, such as early ...
Robert, Krencik, Su-Chun, Zhang
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Training redundant artificial neural networks: Imposing biology on technology

Psychological Research, 1994
One biological principle that is often overlooked in the design of artificial neural networks (ANNs) is redundancy. Redundancy is the replication of processes within the brain. This paper examines the effects of redundancy on learning in ANNs when given either a function-approximation task or a pattern-classification task.
D A, Medler, M R, Dawson
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Developmental biology of a neural cell adhesion molecule

Nature, 1984
A membrane glycoprotein isolated from embryonic brain has been shown to be a ligand in the formation of cell-cell bonds. The molecule, called neural cell adhesion molecule (N-CAM), participates in several aspects of neural development, including the formation of plexiform layers, neurite fasciculation and nerve-muscle interactions.
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Olfactory ensheathing cells: Biology in neural development and regeneration

Progress in Neurobiology, 2010
Olfactory ensheathing cells (OECs) constitute a unique population of glia that accompany and ensheath the primary olfactory axons. They are thought to be critical for spontaneous growth of olfactory axons within the developing and adult olfactory nervous system, and have recently emerged as potential candidates for cell-mediated repair of neural ...
Zhida, Su, Cheng, He
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Transformer Neural Networks, Information Biology, and Alzheimer’s Disease

Alzheimer's & Dementia, 2023
AbstractBackgroundAlzheimer’s disease affects one in ten people older than 65 years, with the prevalence expected to triple by 2030, together with commensurate increases in cost. A comprehensive causal model of Alzheimer’s disease etiology is lacking despite more than three decades of study.
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Neural Tube Defects, Molecular Biology of

2006
Spina bifida is usually grouped together with the closely related conditions anencephaly and craniorachischisis, to form the category of congenital malformations known as neural tube defects (NTDs). NTDs affect approximately 1 in every 1000 pregnancies, equating to a worldwide prevalence of around 120 000 pregnancies with NTDs per year.
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