Results 41 to 50 of about 177,791 (315)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
History-based action selection bias in posterior parietal cortex
Nature Communications, 2017 Past outcomes modulate activity in a diverse set of brain regions however their precise influence on decisions is not known. Here the authors show that posterior parietal cortex neurons encode history-related signals between trials and optogenetic ...
Eun Jung Hwang +3 more
doaj +1 more source
Resolving the neural circuits of anxiety
Nature Neuroscience, 2015 Although anxiety disorders represent a major societal problem demanding new therapeutic targets, these efforts have languished in the absence of a mechanistic understanding of this subjective emotional state. While it is impossible to know with certainty the subjective experience of a rodent, rodent models hold promise in dissecting well-conserved ...
Calhoon, Gwendolyn G., Tye, Kay
openaire +5 more sources
Neural circuits look forward [PDF]
Proceedings of the National Academy of Sciences, 2011 A fundamental step in linking the activity of individual neurons to circuits and animal behavior is to identify their patterns of connectivity. Traditional methods in electrophysiology and microscopy, although powerful, are limited to addressing only a neuron's immediate neighbors (1). A further limitation of these methods is that this can be addressed
Sebnem N, Tuncdemir, Gord, Fishell
openaire +2 more sources
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Novel competition test for food rewards reveals stable dominance status in adult male rats
Scientific Reports, 2021 Social hierarchy is a potent modulator of behavior, that is typically established through overt agonistic interactions between individuals in the group.
Diana F. Costa +2 more
doaj +1 more source
Programmable neuromorphic circuits for spike-based neural dynamics
, 2013 Hardware implementations of spiking neural networks offer promising solutions for a wide set of tasks, ranging from autonomous robotics to brain machine interfaces.
Mostafa Rahimi Azghadi +10 more
core +1 more source
Mapping neural circuits with CLARITY
eLife, 2015 The use of whole-brain imaging has shed new light on the organization of the dopamine system.
Amanda M Willard, Aryn H Gittis
openaire +3 more sources
Deconstruction of a neural circuit for hunger [PDF]
Nature, 2012 Hunger is a complex behavioural state that elicits intense food seeking and consumption. These behaviours are rapidly recapitulated by activation of starvation-sensitive AGRP neurons, which present an entry point for reverse-engineering neural circuits for hunger.
Atasoy, Deniz +3 more
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source