Results 41 to 50 of about 153,307 (268)

Selective dendritic localization of mRNA in Drosophila mushroom body output neurons

eLife, 2021
Memory-relevant neuronal plasticity is believed to require local translation of new proteins at synapses. Understanding this process requires the visualization of the relevant mRNAs within these neuronal compartments.
Jessica Mitchell, Carlas S Smith, Josh Titlow, Nils Otto, Pieter van Velde, Martin Booth, Ilan Davis, Scott Waddell   +7 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

The neural circuits of monogamous behavior

Frontiers in Neural Circuits, 2022
The interest in studying the neural circuits related to mating behavior and mate choice in monogamous species lies in the parallels found between human social structure and sexual behavior and that of other mammals that exhibit social monogamy, potentially expanding our understanding of human neurobiology and its underlying mechanisms.
M. Fernanda López-Gutiérrez, Sara Mejía-Chávez, Sarael Alcauter, Wendy Portillo   +3 more
openaire   +3 more sources

Spatial memory performance is associated with region-specific coordination of hippocampo-cortical sleep oscillations

Scientific Reports
Sleep plays a critical role in memory consolidation, yet how coordination among sleep oscillations across hippocampo-cortical circuits relates to behavioral performance remains incompletely understood. Here, we examined how cross-regional coordination of
Mauricio Caneo, Nelson Espinosa, Alejandro Aguilera, Guillermo Lazcano, Ariel Lara-Vasquez, Pablo Fuentealba   +5 more
doaj   +1 more source

Stimulation of protein synthesis by optogenetic and chemical induction of excitatory synaptic plasticity in hippocampal somatostatin interneurons

Molecular Brain, 2022
Somatostatin-expressing interneurons (SOM-INs) are a major subpopulation of GABAergic cells in CA1 hippocampus that receive excitation from pyramidal cells (PCs) and provide feedback control of synaptic inputs onto PC dendrites.
Ève Honoré, Inês Belo do Nascimento, Isabel Laplante, Jean-Claude Lacaille   +3 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Hippocampo–supramammillary coupling across sleep and wake

Scientific Reports
Hippocampal communication with subcortical circuits reorganizes across sleep–wake states, yet the dynamics of such interactions remain incompletely defined.
M. Caneo, N. Espinosa, G. Lazcano, A. Aguilera, A. Lara-Vasquez, P. Fuentealba   +5 more
doaj   +1 more source

Sensory neurons couple arousal and foraging decisions in Caenorhabditis elegans

eLife, 2023
Foraging animals optimize feeding decisions by adjusting both common and rare behavioral patterns. Here, we characterize the relationship between an animal’s arousal state and a rare decision to leave a patch of bacterial food.
Elias Scheer, Cornelia I Bargmann
doaj   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Infraslow modulation of theta synchrony in the hippocampus circuit during REM sleep

Scientific Reports
Sleep dynamically reorganizes hippocampal activity, but how this reconfiguration supports large-scale coordination across the hippocampal circuit remains unclear.
Nelson Espinosa, Mauricio Caneo, Guillermo Lazcano, Alejandro Aguilera, Ariel Lara-Vasquez, Pablo Fuentealba   +5 more
doaj   +1 more source