Results 41 to 50 of about 162,818 (217)

Coexistence of state, choice, and sensory integration coding in barrel cortex LII/III

Nature Communications
During perceptually guided decisions, correlates of choice are found as upstream as in the primary sensory areas. However, how well these choice signals align with early sensory representations, a prerequisite for their interpretation as feedforward ...
Pierre-Marie Gardères, Sébastien Le Gal, Charly Rousseau, Alexandre Mamane, Dan Alin Ganea, Florent Haiss   +5 more
doaj   +1 more source

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma, Nathan Pavey, Yukiko Tsuji, Amirul Ab Ghapar, Mehdi A.J. van den Bos, Bronwen Orden, Grace Lee, Linda Mekhael, Julie Ryder, Cláudia Santos Silva, David McDonald, Fakhria Kakar, Con Yiannikas, Matthew C. Kiernan, David A. Brown, Parvathi Menon, Steve Vucic   +16 more
wiley   +1 more source

Hippocampal CA1 replay becomes less prominent but more rigid without inputs from medial entorhinal cortex

Nature Communications, 2019
Medial entorhinal cortex (MEC) is involved in memory processes that entail the replay of sequential firing of hippocampal place cells during rest periods and during behaviour.
Alireza Chenani, Marta Sabariego, Magdalene I. Schlesiger, Jill K. Leutgeb, Stefan Leutgeb, Christian Leibold   +5 more
doaj   +1 more source

Adaptive Sample-Size Unscented Particle Filter with Partitioned Sampling for Three-Dimensional High-Maneuvering Target Tracking

Applied Sciences, 2019
High-maneuvering target tracking is a focused application area in radar positioning and military defense systems, especially in three-dimensional space.
Qi Deng, Gang Chen, Huaxiang Lu
doaj   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Gravity‐Dependent Modulation of Downbeat Nystagmus: Insights From Velocity‐Storage Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Downbeat nystagmus varies with head position, a phenomenon termed gravity‐dependent modulation. We aimed to clarify its mechanism using a velocity‐storage model. Methods In 10 patients with downbeat nystagmus due to cerebellar disorders, we recorded eye movements at different pitch‐ and roll‐axis head positions.
Ji‐Hyung Park, Eun‐Hyuk Choi, Jorge Otero‐Millan, David S. Zee, Jeong‐Yoon Choi, Ji‐Soo Kim   +5 more
wiley   +1 more source

Microstructural spine alterations increase neuronal excitability in focal cortical dysplasia Type I

Frontiers in Computational Neuroscience
IntroductionFocal cortical dysplasia (FCD) is a leading cause of drug-resistant epilepsy and has predominantly been associated with impaired inhibitory signaling.
Jawon Gim, Na-Young Seo, Gyu Hyun Kim, Kea Joo Lee, Joon Ho Choi   +4 more
doaj   +1 more source

A Circuit for Gradient Climbing in C. elegans Chemotaxis

Cell Reports, 2015
Animals have a remarkable ability to track dynamic sensory information. For example, the nematode Caenorhabditis elegans can locate a diacetyl odor source across a 100,000-fold concentration range.
Johannes Larsch, Steven W. Flavell, Qiang Liu, Andrew Gordus, Dirk R. Albrecht, Cornelia I. Bargmann   +5 more
doaj   +1 more source

Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory

eLife, 2020
Dietary magnesium (Mg2+) supplementation can enhance memory in young and aged rats. Memory-enhancing capacity was largely ascribed to increases in hippocampal synaptic density and elevated expression of the NR2B subunit of the NMDA-type glutamate ...
Yanying Wu, Yosuke Funato, Eleonora Meschi, Kristijan D Jovanoski, Hiroaki Miki, Scott Waddell   +5 more
doaj   +1 more source

Temporal Interference Stimulation of Centromedian‐Parafascicular Complex in Disorders of Consciousness: A Pilot Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu, Changgeng Song, Dianwei Wu, Xiaoqian Niu, Jianmin Hao, Lijuan Liu, Xiaogang Kang, Wen Jiang   +7 more
wiley   +1 more source