Results 21 to 30 of about 162,818 (217)

NPAS4 recruits CCK basket cell synapses and enhances cannabinoid-sensitive inhibition in the mouse hippocampus

eLife, 2018
Experience-dependent expression of immediate-early gene transcription factors (IEG-TFs) can transiently change the transcriptome of active neurons and initiate persistent changes in cellular function.
Andrea L Hartzell, Kelly M Martyniuk, G Stefano Brigidi, Daniel A Heinz, Nathalie A Djaja, Anja Payne, Brenda L Bloodgood   +6 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Internal State Dependent Odor Processing and Perception—The Role of Neuromodulation in the Fly Olfactory System

Frontiers in Cellular Neuroscience, 2018
Animals rely heavily on their sense of olfaction to perform various vital interactions with an ever-in-flux environment. The turbulent and combinatorial nature of air-borne odorant cues demands the employment of various coding strategies, which allow the
Sercan Sayin, Ariane C. Boehm, Ariane C. Boehm, Johanna M. Kobler, Johanna M. Kobler, Jean-François De Backer, Ilona C. Grunwald Kadow, Ilona C. Grunwald Kadow   +7 more
doaj   +1 more source

Exercise enhances motor skill learning by neurotransmitter switching in the adult midbrain

Nature Communications, 2020
Exercise promotes motor skill learning via unclear mechanisms. Here, the authors show that running wheel training results in neurotransmitter switching in caudal pedunculopontine nucleus neurons of mice.
Hui-quan Li, Nicholas C. Spitzer
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hippocampal synchrony dynamically gates cortical connectivity across brain states

Scientific Reports
Memory consolidation is thought to rely on hippocampo-cortical dialogue orchestrated by three cardinal sleep oscillations: cortical slow oscillations, thalamic spindles, and hippocampal sharp-wave ripples.
G. Lazcano, M. Caneo, A. Aguilera, G. Fernandez-Villalobos, A. Lara-Vasquez, N. Espinosa, P. Fuentealba   +6 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Spatial memory performance is associated with region-specific coordination of hippocampo-cortical sleep oscillations

Scientific Reports
Sleep plays a critical role in memory consolidation, yet how coordination among sleep oscillations across hippocampo-cortical circuits relates to behavioral performance remains incompletely understood. Here, we examined how cross-regional coordination of
Mauricio Caneo, Nelson Espinosa, Alejandro Aguilera, Guillermo Lazcano, Ariel Lara-Vasquez, Pablo Fuentealba   +5 more
doaj   +1 more source

History-based action selection bias in posterior parietal cortex

Nature Communications, 2017
Past outcomes modulate activity in a diverse set of brain regions however their precise influence on decisions is not known. Here the authors show that posterior parietal cortex neurons encode history-related signals between trials and optogenetic ...
Eun Jung Hwang, Jeffrey E. Dahlen, Madan Mukundan, Takaki Komiyama   +3 more
doaj   +1 more source

Novel competition test for food rewards reveals stable dominance status in adult male rats

Scientific Reports, 2021
Social hierarchy is a potent modulator of behavior, that is typically established through overt agonistic interactions between individuals in the group.
Diana F. Costa, Marta A. Moita, Cristina Márquez   +2 more
doaj   +1 more source