Results 31 to 40 of about 162,818 (217)

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Hippocampo–supramammillary coupling across sleep and wake

Scientific Reports
Hippocampal communication with subcortical circuits reorganizes across sleep–wake states, yet the dynamics of such interactions remain incompletely defined.
M. Caneo, N. Espinosa, G. Lazcano, A. Aguilera, A. Lara-Vasquez, P. Fuentealba   +5 more
doaj   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source

Infraslow modulation of theta synchrony in the hippocampus circuit during REM sleep

Scientific Reports
Sleep dynamically reorganizes hippocampal activity, but how this reconfiguration supports large-scale coordination across the hippocampal circuit remains unclear.
Nelson Espinosa, Mauricio Caneo, Guillermo Lazcano, Alejandro Aguilera, Ariel Lara-Vasquez, Pablo Fuentealba   +5 more
doaj   +1 more source

Resolving the prevalence of somatic transposition in Drosophila

eLife, 2017
Somatic transposition in mammals and insects could increase cellular diversity and neural mobilization has been implicated in age-dependent decline.
Christoph D Treiber, Scott Waddell
doaj   +1 more source

Selective dendritic localization of mRNA in Drosophila mushroom body output neurons

eLife, 2021
Memory-relevant neuronal plasticity is believed to require local translation of new proteins at synapses. Understanding this process requires the visualization of the relevant mRNAs within these neuronal compartments.
Jessica Mitchell, Carlas S Smith, Josh Titlow, Nils Otto, Pieter van Velde, Martin Booth, Ilan Davis, Scott Waddell   +7 more
doaj   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Cross-frequency coordination in a hippocampo–cortical circuit during probabilistic reversal learning

Communications Biology
Learning under uncertainty requires detecting latent changes in environmental contingencies and flexibly adjusting choice strategy. To examine hippocampo–cortical circuit dynamics during probabilistic choice behavior, we trained rats on a two-armed ...
Alejandro Aguilera, Nelson Espinosa, Mauricio Caneo, Guillermo Lazcano, Ariel Lara-Vasquez, Pablo Fuentealba   +5 more
doaj   +1 more source

Stimulation of protein synthesis by optogenetic and chemical induction of excitatory synaptic plasticity in hippocampal somatostatin interneurons

Molecular Brain, 2022
Somatostatin-expressing interneurons (SOM-INs) are a major subpopulation of GABAergic cells in CA1 hippocampus that receive excitation from pyramidal cells (PCs) and provide feedback control of synaptic inputs onto PC dendrites.
Ève Honoré, Inês Belo do Nascimento, Isabel Laplante, Jean-Claude Lacaille   +3 more
doaj   +1 more source

Thalamo‐Lesional Connectivity Signatures of Bilateral Tonic–Clonic Seizures in Focal Cortical Dysplasia‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie, Xiaotong Li, Venkata Sita Priyanka Illapani, Leigh N. Sepeta, Jason Schroeder, Chima O. Oluigbo, Madison M. Berl, William D. Gaillard, Nathan T. Cohen   +8 more
wiley   +1 more source