Results 31 to 40 of about 153,307 (268)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
History-based action selection bias in posterior parietal cortex
Nature Communications, 2017 Past outcomes modulate activity in a diverse set of brain regions however their precise influence on decisions is not known. Here the authors show that posterior parietal cortex neurons encode history-related signals between trials and optogenetic ...
Eun Jung Hwang +3 more
doaj +1 more source
Novel competition test for food rewards reveals stable dominance status in adult male rats
Scientific Reports, 2021 Social hierarchy is a potent modulator of behavior, that is typically established through overt agonistic interactions between individuals in the group.
Diana F. Costa +2 more
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Oxytocin Modulation of Neural Circuits [PDF]
, 2017 Oxytocin is a hypothalamic neuropeptide first recognized as a regulator of parturition and lactation which has recently gained attention for its ability to modulate social behaviors. In this chapter, we review several aspects of the oxytocinergic system, focusing on evidence for release of oxytocin and its receptor distribution in the cortex as the ...
Mariela, Mitre +4 more
openaire +2 more sources
Nature CommunicationsCurrent concepts of corticothalamic organization in the mammalian brain are mainly based on sensory systems, with less focus on circuits for higher-order cognitive functions.
Jun Ma +6 more
doaj +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
The neural circuits for arithmetic principles
NeuroImage, 2017 Arithmetic principles are the regularities underlying arithmetic computation. Little is known about how the brain supports the processing of arithmetic principles. The current fMRI study examined neural activation and functional connectivity during the processing of verbalized arithmetic principles, as compared to numerical computation and general ...
Jie Liu +5 more
openaire +2 more sources
Hippocampal synchrony dynamically gates cortical connectivity across brain states
Scientific ReportsMemory consolidation is thought to rely on hippocampo-cortical dialogue orchestrated by three cardinal sleep oscillations: cortical slow oscillations, thalamic spindles, and hippocampal sharp-wave ripples.
G. Lazcano +6 more
doaj +1 more source
Resolving the prevalence of somatic transposition in Drosophila
eLife, 2017 Somatic transposition in mammals and insects could increase cellular diversity and neural mobilization has been implicated in age-dependent decline.
Christoph D Treiber, Scott Waddell
doaj +1 more source