Results 51 to 60 of about 391,417 (288)

Convergent direct and indirect cortical streams shape avoidance decisions in mice via the midline thalamus

Nature Communications
Current concepts of corticothalamic organization in the mammalian brain are mainly based on sensory systems, with less focus on circuits for higher-order cognitive functions.
Jun Ma, John J. O’Malley, Malaz Kreiker, Yan Leng, Isbah Khan, Morgan Kindel, Mario A. Penzo   +6 more
doaj   +1 more source

Resolving the prevalence of somatic transposition in Drosophila

eLife, 2017
Somatic transposition in mammals and insects could increase cellular diversity and neural mobilization has been implicated in age-dependent decline.
Christoph D Treiber, Scott Waddell
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Sensory neurons couple arousal and foraging decisions in Caenorhabditis elegans

eLife, 2023
Foraging animals optimize feeding decisions by adjusting both common and rare behavioral patterns. Here, we characterize the relationship between an animal’s arousal state and a rare decision to leave a patch of bacterial food.
Elias Scheer, Cornelia I Bargmann
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Hippocampal synchrony dynamically gates cortical connectivity across brain states

Scientific Reports
Memory consolidation is thought to rely on hippocampo-cortical dialogue orchestrated by three cardinal sleep oscillations: cortical slow oscillations, thalamic spindles, and hippocampal sharp-wave ripples.
G. Lazcano, M. Caneo, A. Aguilera, G. Fernandez-Villalobos, A. Lara-Vasquez, N. Espinosa, P. Fuentealba   +6 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Genetically Generated Neural Networks I: Representational Effects [PDF]

, 1992
This paper studies several applications of genetic algorithms (GAs) within the neural networks field. After generating a robust GA engine, the system was used to generate neural network circuit architectures.
Marti, Leonardo
core   +2 more sources

Hippocampo–supramammillary coupling across sleep and wake

Scientific Reports
Hippocampal communication with subcortical circuits reorganizes across sleep–wake states, yet the dynamics of such interactions remain incompletely defined.
M. Caneo, N. Espinosa, G. Lazcano, A. Aguilera, A. Lara-Vasquez, P. Fuentealba   +5 more
doaj   +1 more source

Hippocampal CA1 replay becomes less prominent but more rigid without inputs from medial entorhinal cortex

Nature Communications, 2019
Medial entorhinal cortex (MEC) is involved in memory processes that entail the replay of sequential firing of hippocampal place cells during rest periods and during behaviour.
Alireza Chenani, Marta Sabariego, Magdalene I. Schlesiger, Jill K. Leutgeb, Stefan Leutgeb, Christian Leibold   +5 more
doaj   +1 more source