Results 51 to 60 of about 177,791 (315)

Context-dependent serotonin signaling links dietary quality to foraging decisions

Nature Communications
Animals sense their metabolic needs to guide adaptive behaviors partly through serotonin, a neurotransmitter associated with feeding in many species.
Likui Feng, Javier Marquina-Solis, Lishu Yue, Audrey Harnagel, Yarden Greenfeld, Cornelia I. Bargmann   +5 more
doaj   +1 more source

Exploiting device mismatch in neuromorphic VLSI systems to implement axonal delays

, 2012
Axonal delays are used in neural computation to implement faithful models of biological neural systems, and in spiking neural networks models to solve computationally demanding tasks. While there is an increasing number of software simulations of spiking
Sadique Sheik, Sheik, S., Sheik, Sadique, Indiveri, G., Giacomo Indiveri, Elisabetta Chicca, Chicca, Elisabetta, Indiveri, Giacomo, Chicca, Elisabetta ; https://orcid.org/   +8 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Convergent direct and indirect cortical streams shape avoidance decisions in mice via the midline thalamus

Nature Communications
Current concepts of corticothalamic organization in the mammalian brain are mainly based on sensory systems, with less focus on circuits for higher-order cognitive functions.
Jun Ma, John J. O’Malley, Malaz Kreiker, Yan Leng, Isbah Khan, Morgan Kindel, Mario A. Penzo   +6 more
doaj   +1 more source

Resolving the prevalence of somatic transposition in Drosophila

eLife, 2017
Somatic transposition in mammals and insects could increase cellular diversity and neural mobilization has been implicated in age-dependent decline.
Christoph D Treiber, Scott Waddell
doaj   +1 more source

Selective dendritic localization of mRNA in Drosophila mushroom body output neurons

eLife, 2021
Memory-relevant neuronal plasticity is believed to require local translation of new proteins at synapses. Understanding this process requires the visualization of the relevant mRNAs within these neuronal compartments.
Jessica Mitchell, Carlas S Smith, Josh Titlow, Nils Otto, Pieter van Velde, Martin Booth, Ilan Davis, Scott Waddell   +7 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Stimulation of protein synthesis by optogenetic and chemical induction of excitatory synaptic plasticity in hippocampal somatostatin interneurons

Molecular Brain, 2022
Somatostatin-expressing interneurons (SOM-INs) are a major subpopulation of GABAergic cells in CA1 hippocampus that receive excitation from pyramidal cells (PCs) and provide feedback control of synaptic inputs onto PC dendrites.
Ève Honoré, Inês Belo do Nascimento, Isabel Laplante, Jean-Claude Lacaille   +3 more
doaj   +1 more source

Genetic Dissection of Neural Circuits [PDF]

Neuron, 2008
Understanding the principles of information processing in neural circuits requires systematic characterization of the participating cell types and their connections, and the ability to measure and perturb their activity. Genetic approaches promise to bring experimental access to complex neural systems, including genetic stalwarts such as the fly and ...
Luo, Liqun, Callaway, Edward M., Svoboda, Karel   +2 more
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source