Results 51 to 60 of about 180,626 (262)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Hierarchical Random Access Coding for Deep Neural Video Compression

IEEE Access, 2023
Recently, neural video compression networks have obtained impressive results. However, previous neural video compression models mostly focus on low-delay configuration with the order of display being the same as the order of coding.
Nguyen Van Thang, Le Van Bang
doaj   +1 more source

Neural Sparse Topical Coding [PDF]

Proceedings of the 56th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers), 2018
Topic models with sparsity enhancement have been proven to be effective at learn- ing discriminative and coherent latent top- ics of short texts, which is critical to many scientific and engineering applica- tions. However, the extensions of these models require carefully tailored graphi- cal models and re-deduced inference al- gorithms, limiting their
Min Peng 0002, Qianqian Xie, Hua Wang 0002, Yanchun Zhang, Xiuzhen Zhang 0001, Jimin Huang, Gang Tian   +6 more
openaire   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A Low-Rank Method for Characterizing High-Level Neural Computations

Frontiers in Computational Neuroscience, 2017
The signal transformations that take place in high-level sensory regions of the brain remain enigmatic because of the many nonlinear transformations that separate responses of these neurons from the input stimuli.
Joel T. Kaardal, Joel T. Kaardal, Frédéric E. Theunissen, Tatyana O. Sharpee, Tatyana O. Sharpee   +4 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Parallel processing of past and future memories through reactivation and synaptic plasticity mechanisms during sleep

Nature Communications
Every day, we experience new episodes and store new memories. Although memories are stored in corresponding engram cells, how different sets of engram cells are selected for current and next episodes, and how they create their memories, remains unclear ...
Khaled Ghandour, Tatsuya Haga, Noriaki Ohkawa, Chi Chung Alan Fung, Masanori Nomoto, Mostafa R. Fayed, Hirotaka Asai, Masaaki Sato, Tomoki Fukai, Kaoru Inokuchi   +9 more
doaj   +1 more source

Representations of facial features and surface quality in monkey area TE compared to neural network models

Frontiers in Neural Circuits
The shape and spacing of facial features are essential for the perception of emotional expressions and the identification of individuals. The surface quality of faces, such as skin texture, eye twinkle, and hair gloss, is valuable for estimating health ...
Keisuke Shioya, Kazuko Hayashi, Kazuko Hayashi, Bing Li, Narihisa Matsumoto, Keiji Matsuda, Kenichiro Miura, Mark A. G. Eldridge, Mark A. G. Eldridge, Richard C. Saunders, Barry J. Richmond, Yuji Nagai, Naohisa Miyakawa, Takafumi Minamimoto, Shun Katakami, Masato Okada, Kenji Kawano, Kenji Kawano, Yasuko Sugase-Miyamoto   +18 more
doaj   +1 more source