Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
The role of competitive inhibition and top-down feedback in binding during object recognition
Frontiers in Psychology, 2012 How does the brain bind together visual features that are processed concurrently by different neurons into a unified percept suitable for processes such as object recognition?
Dean eWyatte +3 more
doaj +1 more source
Global Neural Activities Changes under Human Inhibitory Control Using Translational Scenario
Brain Sciences, 2020 This study presents a new approach to exploring human inhibition in a realistic scenario. In previous inhibition studies, the stimulus design of go/no-go task generally used a simple symbol for the go and stop signals.
Rupesh Kumar Chikara, Li-Wei Ko
doaj +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Stage-specific roles of FGF2 signaling in human neural development
Stem Cell Research, 2016 This study elucidated the stage-specific roles of FGF2 signaling during neural development using in-vitro human embryonic stem cell-based developmental modeling.
Marta Grabiec +6 more
doaj +1 more source
Neural mechanisms underlying anxiety-related deficits of attentional inhibition: direct ERP evidence from the Pd component [PDF]
, 2021 Liping Hu +5 more
openalex +1 more source
Neural Evidence for Feature-based Distractor Inhibition
Journal of Cognitive NeuroscienceAbstract Interference from a salient distractor is typically reduced when the appearance of the distractor follows either spatial or feature-based regularities. Although there is a growing body of literature on distractor location learning, the understanding of distractor feature learning remains limited.
Aylin A. Hanne, Sizhu Han, Anna Schubö
openaire +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Precision Medicine Care in ADHD: The Case for Neural Excitation and Inhibition [PDF]
, 2021 Ping C. Mamiya +2 more
openalex +1 more source