Behavioral and neural mechanisms of latent inhibition
Fear is an adaptive emotion that serves to protect an organism against potential dangers. It is often studied using classical conditioning paradigms where a conditioned stimulus is paired with an aversive unconditioned stimulus to induce a threat response.
Miller, Dylan B. +3 more
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Rationale: Both attention deficit-/hyperactivity disorder (ADHD) and alcohol use disorder (AUD) are accompanied by deficits in response inhibition. Furthermore, the prevalence of comorbidity of ADHD and AUD is high.
Sarah Gerhardt +10 more
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Rate-Dependent Depression of the Hoffmann Reflex: Practical Applications in Painful Diabetic Neuropathy [PDF]
Measurement of the rate-dependent depression (RDD) of the Hoffmann (H) reflex, a technique developed over half a century ago, is founded on repeated stimulation of the H-reflex with tracking of sequentially evoked H-wave amplitudes in the resulting ...
Lu Han, Nigel A. Calcutt, Xiajun Zhou
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Background: Diverse forms of long-term potentiation (LTP) have been described, but one of the most investigated is encountered in the glutamatergic synapses of the hippocampal cornu Ammonis (CA1) subfield.
Selvin Z. Reyes-Garcia +6 more
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Multiple roles of Activin/Nodal, bone morphogenetic protein, fibroblast growth factor and Wnt/β-catenin signalling in the anterior neural patterning of adherent human embryonic stem cell cultures [PDF]
Several studies have successfully produced a variety of neural cell types from human embryonic stem cells (hESCs), but there has been limited systematic analysis of how different regional identities are established using well-defined differentiation ...
Giuseppe Lupo +8 more
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Dynamic neural field with local inhibition [PDF]
A lateral-inhibition type neural field model with restricted connections is presented here and represents an experimental extension of the continuum neural field theory (CNFT) by suppression of the global inhibition. A modified CNFT equation is introduced and allows for a locally defined inhibition to spatially expand within the network and results in ...
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Neural and Neurochemical Mechanisms of Pain Inhibition [PDF]
Recent studies which suggest the existence of an endogenous neural substrate of pain inhibition are reviewed. Electrical stimulation of some areas of the medial brain stem in laboratory rats has produced a dramatic degree of analgesia. Such stimulation-produced analgesia is partially blocked by an opiate antagonist drug.
J C, Liebeskind, J E, Sherman, T, Cannon
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Feedforward inhibition and synaptic scaling - two sides of the same coin? [PDF]
Feedforward inhibition and synaptic scaling are important adaptive processes that control the total input a neuron can receive from its afferents. While often studied in isolation, the two have been reported to co-occur in various brain regions.
Cristina Savin +11 more
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Decorrelation by Recurrent Inhibition in Heterogeneous Neural Circuits [PDF]
The activity of neurons is correlated, and this correlation affects how the brain processes information. We study the neural circuit mechanisms of correlations by analyzing a network model characterized by strong and heterogeneous interactions: excitatory input drives the fluctuations of neural activity, which are counterbalanced by inhibitory ...
Alberto Bernacchia, Xiao-Jing Wang
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What do we really know about cognitive inhibition? Task demands and inhibitory effects across a range of memory and behavioural tasks [PDF]
The authors (SN, principal investigator and MDM as co-investigator) received funding from the British Academy for this research (http://www.britac.ac.uk/).
Saima Noreen (462029) +9 more
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